35 documents found, page 1 of 4

Clinical Outcomes of Chemo-Immunotherapy for Extensive Stage Small Cell Lung Ca...

Small cell lung cancer (SCLC) is an aggressive type of lung cancer. Recent studies have provided a new hope by adding atezolizumab to the standard treatment of extensive disease SCLC (E-SCLC). The aim of our study was to evaluate the real-life performance of atezolizumab plus chemotherapy in extensive stage SCLC in a Portuguese setting. Data was collected on twenty patients (70% were male with a mean age of 66....

Omega-3 polyunsaturated fatty acids and cognitive decline in adults with non-de...

Background/Objectives: As global aging accelerates, prevalence of mild cognitive impairment (MCI) continues to rise, challenging healthcare systems and diminishing older adults’ quality of life. There is great interest in better understanding the neuroprotective/anti-inflammatory properties of omega-3 polyunsaturated fatty acids but the results from many published studies in humans come to different conclusions...

Pembrolizumab plus Pemetrexed and Platinum in Metastatic Non-Squamous Non-Small...

First-line therapy for metastatic non-small-cell lung cancer without targetable mutations is platinum-based chemotherapy plus pembrolizumab if programmed death ligand 1 is < 50%. The aim of this real-life retrospective study is to assess the efficacy and safety of this therapy. This retrospective observational study was conducted at the Pulmonary Oncology Department in Unidade Local de Saúde Santa Maria, in ...

Immunotherapy in lung cancer brain metastases

Brain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunothera...

Long-term Follow-up of Resected EGFR-mutated Non-small Cell Lung Cancer: A Real...

Surgically resected epidermal growth factor receptor-mutated non-small cell lung cancer continues to carry a substantial risk of recurrence. The aim of this retrospective, single-center study, conducted at a Portuguese tertiary hospital was to evaluate the clinical course of these patients, diagnosed between 2016 and 2020, with the final clinical data review in November, 2024. A total of 48 patients were includ...

Solitary Fibrous Tumors of the Chest: Case Series from a Portuguese Center

The solitary fibrous tumor is a rare mesenchymal tumor with predilection for the pleura. Most times it is an incidental diagnosis. Surgery is the recommended treatment. Most solitary fibrous tumors (SFTs) exhibit indolent behavior; however, 10% to 25% may experience recurrence. The aim of this retrospective analysis is to characterize their presentation, therapeutic approach and recurrence and was conducted at ...

A importância do papel do EEER na gestão de quedas em contexto hospitalar - qua...

Em contexto hospitalar a ocorrência de quedas em adultos representa um problema grave que exige a intervenção do Enfermeiro Especialista em Enfermagem de Reabilitação (EEER) no sentido da implementação de medidas preventivas deste fenómeno. As lesões delas resultantes, provocam o declínio funcional do utente, aumento do tempo de internamento e custos em saúde associados, e reduzem a sua qualidade de vida. O EEE...

The influence of diet and obesity in Lynch syndrome: what do we know so far

Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS’s cl...

Correction: IgG antibodies to SARS-CoV-2 in asymptomatic blood donors at two ti...

Acute hospitalization of cancer community-based patients: a cross sectional loo...

Background - Cancer-related malnutrition is prevalent. Moreover, nutritional status can be dynamic, resulting from a cumulative risk of deterioration, specially if multimodal treatments are proposed. Nowadays, due to treatment advances, more people living with cancer are being managed as community-based outpatients. Systematic nutritional risk identification should be conducted and established throughout the on...