5 documents found, page 1 of 1
Barriers faced by patients in the diagnosis of multidrug-resistant tuberculosis...
Bhering,Marcela; Dalcolmo,Margareth; Sarubbi Júnior,Vicente; Kritski,AfrânioABSTRACT OBJECTIVE To understand patients’ narratives about the barriers they faced in the diagnosis and treatment of multidrug-resistant tuberculosis, and their consequences in Rio de Janeiro State, Brazil. METHODS This is a qualitative cross-sectional study with non-probabilistic sampling. A theoretical saturation criterion was considered for composing the number of interviewees. Semi-structured interviews we...
Predictors of mortality in multidrug-resistant tuberculosis patients from Brazi...
Gayoso,Regina; Dalcolmo,Margareth; Braga,José Ueleres; Barreira,DraurioABSTRACT Objectives To determine the main predictors of death in multidrug-resistant (MDRTB) patients from Brazil. Design Retrospective cohort study, a survival analysis of patients treated between 2005 and 2012. Results Of 3802 individuals included in study, 64.7% were men, mean age was 39 (1-93) years, and 70.3% had bilateral pulmonary disease. Prevalence of human immunodeficiency virus (HIV) was 8.3%. There ...
New and repurposed drugs to treat multidrug- and extensively drug-resistant tub...
Silva,Denise Rossato; Dalcolmo,Margareth; Tiberi,Simon; Arbex,Marcos Abdo; Munoz-Torrico,Marcela; Duarte,Raquel; D’Ambrosio,Lia; Visca,DinaABSTRACT Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher success rates, the overall rate of favorable outcomes of M/XDR-TB treatment is only 54%, or much lower when the spectrum of drug resistance is beyond that of...
Is there a rationale for pulmonary rehabilitation following successful chemothe...
Muñoz-Torrico,Marcela; Rendon,Adrian; Centis,Rosella; D'Ambrosio,Lia; Fuentes,Zhenia; Torres-Duque,Carlos; Mello,Fernanda; Dalcolmo,MargarethABSTRACT The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no...
Preditores dos desfechos do tratamento da tuberculose
Orofino,Renata de Lima; Brasil,Pedro Emmanuel Americano do; Trajman,Anete; Schmaltz,Carolina Arana Stanis; Dalcolmo,Margareth; Rolla,Valéria CavalcantiOBJETIVO: Analisar os desfechos do tratamento da tuberculose e seus preditores. MÉTODOS: Estudo longitudinal de coorte de pacientes com tuberculose tratados entre 2004 e 2006 no Instituto de Pesquisa Evandro Chagas, na cidade do Rio de Janeiro. As razões de risco ajustadas (RRa) dos preditores foram estimadas. RESULTADOS: Foram incluídos 311 pacientes. As taxas de cura, de abandono, de mortalidade e de falha te...