2 documents found, page 1 of 1
Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cel...
Severino, P; Silva, M; Carrascal, M; Malagolini, N; Chiricolo, M; Venturi, G; Barbaro Forleo, R; Astolfi, A; Catera, M; Videira, P; Dall'Olio, FTreatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-associated O-linked carbohydrates: the disaccharide (Galß1,3GalNAc) Thomsen-Friedenreich (T) antigen, and its sialylated counterpart (Siaa2,3Galß1,3GalNAc) sialyl-T (sT), synthesized by sialyltransferase...
Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...
Carrascal, M; Severino, P; Cabral, MG; Silva, M; Ferreira, JA; Calais da Silva, F; Quinto, H; Pen, C; Ligeiro, D; Lara Santos, L; Dall'Olio, FDespite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...