6 documents found, page 1 of 1
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease
Carvalho, Miguel M.; Campos, Filipa L.; Marques, Mariana; Cunha, Carina Isabel Soares; Kokras, Nikolaos; Dalla, Christina; Leite-Almeida, HugoThe use of dopamine replacement therapies (DRT) in the treatment of Parkinson's disease (PD) can lead to the development of dopamine dysregulation syndrome (DDS) and impulse control disorders (ICD), behavioral disturbances characterized by compulsive DRT self-medication and development of impulsive behaviors. However, the mechanisms behind these disturbances are poorly understood. In animal models of PD, the as...
Tau protein is essential for stress-induced brain pathology
Lopes, Sofia; Silva, João Vaz; Pinto, Vítor; Dalla, Christina; Kokras, N.; Bedenk, Benedikt; Mack, Natalie; Czisch, Michael; Almeida, Osborne F. X.Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mic...
Stress induced risk-aversion is reverted by D2/D3 agonist in the rat
Morgado, Pedro; Marques, Fernanda; Ribeiro, Beatriz; Leite-Almeida, Hugo; Pêgo, José M.; Rodrigues, Ana J.; Dalla, Christina; Kokras, Nikos; Sousa, NunoStress exposure triggers cognitive and behavioral impairments that influence decision-making processes. Decisions under a context of uncertainty require complex reward-prediction processes that are known to be mediated by the mesocorticolimbic dopamine (DA) system in brain areas sensitive to the deleterious effects of chronic stress, in particular the orbitofrontal cortex (OFC). Using a decision-making task, we...
Neudesin is involved in anxiety behavior: structural and neurochemical correlates
Novais, Ashley Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.; Dalla, ChristinaNeudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...