91 documents found, page 1 of 10
Understanding lactoferrin multifunctionality by analyzing the full spectrum of ...
Ferreira, Sofia; Guedes, Joana P.; Rocha, Juliana F.; Sousa, Sérgio F.; Rodrigues, L. R.; Côrte-Real, Manuela; Soares, Pedro; Cátia S. PereiraLactoferrin (LF) is a multifunctional protein involved in critical biological processes such as immune response, antimicrobial activity, and iron regulation [1]. Its diverse roles include inhibiting inflammation, infections, and carcinogenesis [2], as well as modulating cellular processes by targeting proton-pumping ATPases such as V-ATPases in cancer cells [3], F- ATPases in bacteria [4], and P-ATPases in yeas...
Preserving visual acuity: a compelling 12-year case study of controlling neovas...
Tomás, Rita O.; Campos, António; Oliveira, Nuno; Soares, Pedro; Sousa, João P.Introduction: In neovascular age-related macular degeneration (nAMD) trials, anti-VEGF injection frequency decreases after the first year, while outcomes remain primarily related to the number of injections. To the best of our knowledge, there are no reports of maintaining the best corrected visual acuity (BCVA) for more than 7 years in extension studies. Objective To report a 12-year follow-up of a real-world ...
Tuberculosis: integrated studies for a complex disease 2050
Rezaei, Nima; Hosseini, Nastaran-Sadat; Saghazadeh, Amene; Fateh, Abolfazl; Duse, Adriano; Ahmad, Aijaz; Braley, Alexander E.; Tahta, AlicanTuberculosis (TB) has been a disease for centuries with various challenges [1]. Like other places where challenges and opportunities come together, TB challenges were the inspiration for the scientific community to mobilize different groups for the purpose of interest. For example, with the emergence of drug resistance, there has been a huge volume of research on the discovery of new medicines and drug delivery...
Flying under the radar - impact and factors influencing asymptomatic DENV infec...
Henriques, Paulo; Rosa, Alexandra; Caldeira-Araújo, Helena; Soares, Pedro; Vigário, Ana MargaridaThe clinical outcome of DENV and other Flaviviruses infections represents a spectrum of severity that ranges from mild manifestations to severe disease, which can ultimately lead to death. Nonetheless, most of these infections result in an asymptomatic outcome that may play an important role in the persistent circulation of these viruses. Also, although little is known about the mechanisms that lead to these as...
A glimpse at an early stage of microbe domestication revealed in the variable g...
Silva, Margarida; Pontes, Ana; Franco-Duarte, Ricardo; Soares, Pedro; Sampaio, José Paulo; Sousa, Maria João; Brito, Patrícia HMicrobe domestication has a major applied relevance but is still poorly understood from an evolutionary perspective. The yeast Torulaspora delbrueckii is gaining importance for biotechnology but little is known about its population structure, variation in gene content or possible domestication routes. Here, we show that T. delbrueckii is composed of five major clades. Among the three European clades, a lineage ...
Functional and sequence-based metagenomics to uncover carbohydrate-degrading en...
Pereira, Cátia Sofia Santos; Sousa, Joana; Costa, Ângela Maria Araújo; Santos, A. O.; Rito, Teresa; Soares, Pedro; Franco-Duarte, RicardoThe renewable, abundant, and low-cost nature of lignocellulosic biomass can play an important role in the sustainable production of bioenergy and several added-value bioproducts, thus providing alternative solutions to counteract the global energetic and industrial demands. The efficient conversion of lignocellulosic biomass greatly relies on the catalytic activity of carbohydrate-active enzymes (CAZymes). Find...
INTERCOMPARAÇÃO DE SIMULAÇÕES NUMÉRICAS COM MODELOS ATMOSFÉRICOS ACOPLADOS A MO...
Couto, Flavio; Salgado, Rui; Filippi, Jean-Baptiste; Baggio, Roberta; Kartsios, Stergios; Cardoso, Rita; Soares, Pedro; Campos, CátiaA propagação do fogo associada à atividade piro-convectiva extrema é atualmente altamente imprevisível e difícil de combater. Este relatório apresenta os principais resultados de simulações realizadas a partir do acoplamento entre modelos de resolução de nuvens e modelos de propagação de fogo, nomeadamente MesoNH/ForeFire, WRF/FIRE e WRF/SFIRE. Os códigos acoplados foram utilizados no estudo dos mega incêndios ...
Evaluating data sharing of SARS-CoV-2 genomes for molecular epidemiology across...
Rito, Teresa; Fernandes, Pedro; Duarte, Raquel; Soares, PedroFollowing the emergence of COVID-19 in December 2019, caused by the coronavirus SARS-CoV-2, the disease spread dramatically worldwide. The use of genomics to trace the dissemination of the virus and the identification of novel variants was essential in defining measures for containing the disease. We aim to evaluate the global effort to genomically characterize the circulating lineages of SARS-CoV-2, considerin...
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Weste...
Amorim, Ricardo; Simões, Inês C. M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; Tavares, Ludgero C.Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment are underw...
Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catech...
Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; Remião, FernandoIncreased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely linked to the neurodegeneration observed in Parkinson’s Disease (PD). Caffeic acid (CA)-based antioxidants were developed, and their inhibitory activities towards monoamine oxidases (MAOs) and catechol O-methyltransferases (COMT) were screened. The results showed that the incorporation of an extra double bond maintained or ...