Studies on the development of salivary composition in the first year of life can promote the information about the immune maturation in children. Saliva is the most easily available and accessible body fluid, which makes it one of the most sought after tools in diagnostic and biomarks. In this context, this thesis, constituted by 01 article aimed to characterize salivary proteins in the first months of life usi...
Autoimmune hepatitis (AIH) is an inflammatory chronic liver disease of unknown etiology found predominantly in females, leading when untreated, to cirrhosis. It is a rare disease in the childhood, corresponding to about 10% of patients with chronic hepatitis, but exhibits high mortality. It is characterized by hipergammaglobulinemia, organ nonspecific circulating autoantibodies, and an inflammatory liver-infilt...
Objective: The aim of the present study was to investigate the protein profile of children with different levels of protein–energy undernutrition (PEU) through a proteomic approach of human whole saliva. Methods: Initially, saliva samples of children with mild, moderate, and severe PEU were collected and lyophilized. Saliva samples of healthy children were used as controls. Samples were analyzed for total prote...