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Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blo...
Silva, Camila Meirelles S.; Wanderley, Carlos Wagner S.; Veras, Flavio P.; Sonego, Fabiane; Nascimento, Daniele C.; Gonçalves, Augusto V.Made available in DSpace on 2022-04-29T08:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23; Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely...
Purification and primary structure determination of a galactose-specific lectin...
Silva, Helton Colares; Nagano, C. S.; Souza, Luis A.G.; Nascimento, K. S.; Isídro, Renato; Delatorre, Plínio; Rocha, Bruno Anderson Matias daVatairea guianensis seeds, a typical plant from the Brazilian Amazon region that belongs to the Dalbergieae tribe, possess a lectin that was isolated by precipitation with solid ammonium sulfate followed by guar gum affinity chromatography. This lectin was named VGL. The V. guianensis lectin strongly agglutinated rabbit erythrocytes and was inhibited by d-galactose and d-galactose-derived sugars, especially N-a...