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Global guideline for the diagnosis and management of candidiasis: an initiative...

Cornely, Oliver A.; Sprute, Rosanne; Bassetti, Matteo; Chen, Sharon C-A; Groll, Andreas H.; Kurzai, Oliver; Lass-Flörl, Cornelia

Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individual...


Environmental and bioclimatic factors influencing yeasts and molds distribution...

Cogliati, M.; Arikan-Akdagli, S.; Barac, A.; Bostanaru, A. C.; Brito, S.; Çerikçioğlu, N.; Efstratiou, M. A.; Ergin, Ç.; Esposto, M. C.; Frenkel, M.

The present study employed data collected during the Mycosands survey to investigate the environmental factors influencing yeasts and molds distribution along European shores applying a species distribution modelling approach. Occurrence data were compared to climatic datasets (temperature, precipitation, and solar radiation), soil datasets (chemical and physical properties), and water datasets (temperature, sa...


Novel clinical and laboratorial challenges in Aspergillosis

Sabino, Raquel Filipa Pinheiro; Veríssimo, Cristina

In recent years, research in the areas of Aspergillus and aspergillosis has continued to advance rapidly, including advancements in genomics, immunological studies, clinical areas, and diagnostic areas. Recently, new risk groups for the development of aspergillosis have emerged—patients with influenza- or COVID-19-ssociated pulmonary aspergillosis. The rise and spread of antifungal resistances have also become ...


Towards a global perspective of environmental health : defining the research gr...

Virgolino, Ana; Antunes, Francisco; Santos, Osvaldo; Costa, Andreia; Matos, Margarida Gaspar de; Bárbara, Cristina; Bicho, Manuel; Caneiras, Catia

Environmental health is at the intersection between health and the environment. However, it still has a recent (and narrow) history as a scientific area, mainly addressing human biomonitoring and toxicological issues. Only recently additional environmental ‘layers’, other than the traditional chemical, biological and physical environmental determinants, have been considered. This broader perspective of environm...


Candida auris : emergência recente de um fungo patogénico multirresistente

Antunes, Francisco; Veríssimo, Cristina; Ayres Pereira, Álvaro; Sabino, Raquel Filipa Pinheiro

Candida auris was first described as a new species back in 2009. Although it differs markedly from other Candida species, this species can be misidentified as other yeasts in the routine microbiology laboratories. Therefore, its identification to species level should be confirmed by reference laboratories. Candida auris exhibits potential to cause invasive infections, and frequently shows a multidrugresistance ...


Culture media and sampling collection method for Aspergillus spp. assessment : ...

Viegas, Carla; Dias, Marta; Carolino, Elisabete; Sabino, Raquel Filipa Pinheiro

Culturing is still the most widely used method for determining fungal growth. Thus, is important to identify the most suitable culture media to assess Aspergillus spp. The aim of this study was to analyze data obtained from previous studies, aiming at identifying the most suitable culture media (malt extract agar (MEA) or dichloran-glycerol agar (DG18) to assess Aspergillus spp. isolation and growth. This study...


Candida auris, an agent of hospital-associated outbreaks : which challenging is...

Sabino, Raquel Filipa Pinheiro; Veríssimo, Cristina; Ayres Pereira, Álvaro; Antunes, Francisco

The emergence of Candida auris is considered as one of the most serious problems associated with nosocomial transmission and with infection control practices in hospital environment. This multidrug resistant species is rapidly spreading worldwide, with several described outbreaks. Until now, this species has been isolated from different hospital surfaces, where it can survive for long periods. There are multipl...


Algorithm to assess the presence of Aspergillus fumigatus resistant strains : t...

Viegas, Carla; Almeida, Beatriz; Caetano, Liliana Aranha; Afanou, Anani; Straumfors, Anne; Veríssimo, Cristina; Gonçalves, Paulo

Association between selection pressure caused by the use of azole fungicides in sawmills and the development of fungal resistance has been described. The aim of this study was to implement an algorithm to assess the presence of Aspergillus section Fumigati resistant strains in sawmills. Eighty-six full-shift inhalable dust samples were collected from eleven industrial sawmills in Norway. Different culture media...


Azole-resistant Aspergillus fumigatus harboring the TR34/L98H mutation : first ...

Gonçalves, Paulo; Melo, Aryse; Dias, Marta; Almeida, Beatriz; Caetano, Liliana Aranha; Veríssimo, Cristina; Viegas, Carla

The frequency in detection of azole-resistant Aspergillus fumigatus isolates has increased since 2010. In Portugal, the section Fumigati is one of the most frequent, and resistant strains to have been found in clinical and environmental contexts. Although several cryptic species within the Fumigati section show intrinsic resistance to azoles, one factor driving (acquired) resistance is selective pressure derivi...


Aspergillosis, avian species and the one health perspective : the possible impo...

Melo, Aryse Martins; Stevens, David A.; Tell, Lisa A.; Veríssimo, Cristina; Sabino, Raquel Filipa Pinheiro; Xavier, Melissa Orzechowski

The One Health context considers health based on three pillars: humans, animals, and environment. This approach is a strong ally in the surveillance of infectious diseases and in the development of prevention strategies. Aspergillus spp. are fungi that fit substantially in this context, in view of their ubiquity, as well as their importance as plant pathogens, and potentially fatal pathogens for, particularly, ...


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