2 documents found, page 1 of 1
Reprogramming CD8+ T-cell Branched N-Glycosylation Limits Exhaustion, Enhancing...
Azevedo, CM; Xie, B; Gunn, WG; Peralta, RM; Dantas, CS; Fernandes-Mendes, H; Joshi, S; Dean, V; Almeida, P; Wilfahrt, D; Mendes, N; Portero, JLT-cell therapies have transformed cancer treatment. While surface glycans have been shown to play critical roles in regulating T-cell development and function, whether and how the glycome influences T cell–mediated tumor immunity remains an area of active investigation. In this study, we show that the intratumoral T-cell glycome is altered early in human colorectal cancer, with substantial changes in branched N...
N-Glycans as fundamental immune-checkpoints at the frontiers of inflammation, a...
Azevedo, CM; Santos-Pereira, B; Leite-Gomes, E; Rodrigues, CS; Dantas, CS; Faria, G; Nogueira, R; Almeida, P; Tavares-Gomes, L; Gaifem, J; Alves, IOs glicanos revestem a superfície de praticamente todas as células, dando origem ao chamado glicocálice. Os glicanos, e particularmente os N- glicanos, são peças-chave na definição do destino e da natureza da resposta imune, participando tanto de vias pró-inflamatórias quanto anti-inflamatórias presentes em processos inflamatórios, autoimunes e no câncer. Os glicanos e as proteínas de ligação a glicanos (GBPs) ...