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WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition...
De-Castro, ARG; Rodrigues, DRM; De-Castro, MJG; Vieira, N; Vieira, C; Carvalho, AX; Gassmann, R; Abreu, CMC; Dantas, TThe dynein-2 motor complex drives retrograde intraflagellar transport (IFT), playing a pivotal role in the assembly and functions of cilia. However, the mechanisms that regulate dynein-2 motility remain poorly understood. Here, we identify the Caenorhabditis elegans WDR60 homologue, WDR-60, and dissect the roles of this intermediate chain using genome editing and live imaging of endogenous dynein-2/IFT componen...
Date: 2022
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Origin: Repositório Aberto da Universidade do Porto