9 documents found, page 1 of 1
Addressing Inequality in the COVID-19 Pandemic in Africa
Pêgo, Ana Catarina; Lima, Illyane Sofia; Gozzelino, RaffaellaOn 30 January 2020, WHO declared COVID-19 a public health emergency of global concern. COVID-19 became pandemic on 11 March 2020, and spread unprecedently. No country was prepared to face its impact. Major fears started to be expressed for Africa, where dramatic consequences were expected, due to the weakness of health systems. In this review, we related major concerns, at that time but still present, regarding...
Organization of the CO VID-19 response in Cape Verde - The role of the National...
Lima Mendonça, Maria da Luz; Gozzelino, RaffaellaIntroduction: The COVID-19 pandemic has brought unprecedented challenges to healthcare systems and economies world- wide. In countries with fragile healthcare systems, like Cape Verde, it is worth to highlight the resilience of the population and local authorities in response to this unprecedented reality. The implementation of rigorous public health measures, since the beginning of the pandemic, played a key r...
DNA damage independent inhibition of NF-κB transcription by anthracyclines
Pedroso, Dora; Chora, Ângelo Ferreira; Kyriakou, Eleni; Pejanovic, Nadja; Colaço, Henrique; Gozzelino, Raffaella; Barros, André; Willmann, KatharinaAnthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here, we show that the extensively used anthracyclines Doxorubicin, Daunorubicin, and Epirubicin decrease the transcription of nuclear factor kappa B (NF-κB)-dependent gene targ...
The importance of iron in pathophysiologic conditions
Gozzelino, Raffaella; Arosio, PaoloBiological iron is necessary for vital functions and also potentially toxic to the organisms. This dual effect raised the interest of many investigators to study the mechanisms controlling its homeostasis that are altered in many pathologic conditions. Recently the understanding of iron metabolism significantly improved with the discovery of genes responsible for genetic disorders, such as hemochromatosis, the ...
Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria
Gozzelino, Raffaella; Andrade, Bruno Bezerril; Larsen, Rasmus; Luz, Nívea Farias; Vanoaica, Liviu; Seixa, Elsa; Coutinho, AntonioTexto completo: acesso restrito. p. 693–704; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-06T17:00:53Z No. of bitstreams: 1 Manoel Barral Netto.pdf: 1535112 bytes, checksum: 511e0bbfefaaf21eb5c649bab7871771 (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-21T16:43:41Z (GMT) No. of bitstreams: 1 Manoel Barral Netto.pdf: 1535112 bytes, checksum: 511e...
Tissue damage control in disease tolerance
Soares, Miguel P; Gozzelino, Raffaella; Weis, SebastianImmune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptatio...
Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechani...
Penha-Gonçalves, Carlos; Gozzelino, Raffaella; de Moraes, Luciana V.Plasmodium infection during gestation may lead to severe clinical manifestations including abortion, stillbirth, intrauterine growth retardation, and low birth weight. Mechanisms underlying such poor pregnancy outcomes are still unclear. In the animal model of severe placental malaria (PM), in utero fetal death frequently occurs and mothers often succumb to infection before or immediately after delivery. Plasmo...
Anthracyclines induce DNA damage response-mediated protection against severe se...
Figueiredo, Nuno; Chora, Ângelo Ferreira; Raquel, Maria Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; Moita, CatarinaSevere sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage ...
Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases
Larsen, Rasmus; Gouveia, Zélia; Soares, Miguel P.; Gozzelino, RaffaellaHeme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of reactive oxygen species. Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, u...