22 documents found, page 1 of 3
Infective endocarditis risk in patients with bicuspid aortic valve: systematic ...
Couto Pereira, Sara Cristina; Abrantes, Ana; António, Pedro Silverio; Morais, Pedro; Santos De Sousa, Catarina Isabel; David, Cláudio; Pinto, Fausto J.Background: Antibiotic prophylaxis in bicuspid aortic valve patients is currently a matter of debate. Although it is no longer recommended by international guidelines, some studies indicate a high risk of infective endocarditis. We aim to evaluate the risk of native valve infective endocarditis in bicuspid aortic valve patients and compare to individuals with tricuspid aortic valve. Methods: Study search of lon...
The effect of catheter-based sham renal denervation in hypertension: systematic...
Fernandes, Adriana; David, Cláudio; Pinto, Fausto J.; Costa, João; Ferreira, Joaquim J; Caldeira, DanielBackground: Renal denervation (RDN) has emerged in recent years as a possible treatment for hypertension. The first sham-controlled trial showed a small magnitude and non-significant in the blood pressure (BP) lowering effect, also due to a substantial decrease of BP in sham arm. Considering this, we aimed to quantify the magnitude of BP decrease within the sham arm of Randomized Controlled Trials (RCT) with RD...
The sham effect of invasive interventions in chronic coronary syndromes: a syst...
Palma, Catarina; David, Cláudio; Fernandes, Ricardo M.; Pinto, Fausto J.; Costa, João; Ferreira, Joaquim J; Caldeira, DanielBackground: Some patients with chronic coronary syndromes undergo invasive procedures but the efficacy of such interventions remains to be robustly established by randomised sham-controlled trials (RCTs). Purpose: To determine the sham effect in patients with chronic coronary syndromes enrolled in RCTs by performing a systematic review and meta-analysis. Methods: In April 2022, we performed a literature search ...
Clinical effects of off-label reduced doses of Direct Oral Anticoagulants: a sy...
Pereira, Mariana Q.; David, Cláudio; Almeida, Ana G.; Brito, Dulce; Pinto, Fausto J.; Caldeira, DanielBackgound: Atrial Fibrillation (AF) is the most prevalent cardiac arrhythmia among older patients, associated with thromboembolic events. Direct Oral Anticoagulants (DOAC) are the treatment of choice for most patients, but its use may have risks on standard dose. However, it is still unclear the effects related with the use of a lower dose off labelled DOAC. Objectives: We conducted a systematic review and meta...
Cardiovascular and respiratory safety of sedation strategies used in transesoph...
Manuel Freitas, Tiago; David, Cláudio; Almeida, Ana G.; Pinto, Fausto J.; Costa, João; Caldeira, DanielTRANSESOPHAGEAL ECHOCARDIOGRAPHY (TEE) is carried out in various clinical settings, with an increasing importance, and sedation usually is required to perform it. Several sedative agents are available, and the authors aimed to compare the cardiovascular and respiratory safety of the strategies used for sedation in TEE through a systematic review with network meta-analysis (NMA). The MEDLINE, CENTRAL, EMBASE, an...
Antithrombotic therapy recommendations in the European Society of Cardiology Gu...
Santos, Catarina M.; Prada, Luísa; David, Cláudio; Costa, João; Ferreira, Joaquim J.; Pinto, Fausto J.; Caldeira, DanielIntroduction: Criticisms have been raised against the sole use of p-value in interpreting results from randomized controlled trials (RCTs). Additional tools have been suggested, like the fragility index (FI), a measure of a trial’s robustness/fragility, and derivative measures. The FI is the minimum number of patients who would have to be converted from nonevents to events, in the group with the least events, f...
The Eustachian valve : a structure not so innocent
Rodrigues, T. E. Graça; Plácido, Rui; David, Cláudio; Gonçalves, Sónia; Pinto, Fausto J.; Almeida, Antonio Bugalho deBackground: The eustachian valve is an embryological remnant of the inferior vena cava (IVC) valve. It is sually absent or inconspicuous and has no known function in the normal adult. However, there are reports suggesting that the EV is not as innocent as we thought. The EV can be a site of infective vegetations or be mistaken for a thrombus or tumor. The EV can also make interventional procedures (closure of A...
The incidence of thrombotic events with idarucizumab and andexanet alfa : a sys...
Rodrigues, André Oliveira; David, Cláudio; Ferreira, Joaquim J; Pinto, Fausto J.; Costa, João; Caldeira, DanielIntroduction: Direct thrombin inhibitor, dabigatran and factor Xa inhibitors, apixaban, edoxaban, and rivaroxaban (DOACs/NOACs), are currently the first-choice drugs in some indications. Life-threatening bleeding occurring during DOACs treatment may benefit from the use of reversal agents, however there are some concerns regarding potential rebound thrombotic events. In this systematic review we aimed to estima...
Influenza vaccination in patients with heart failure : a systematic review and ...
Rodrigues, Bárbara Sucena; David, Cláudio; Costa, João; Ferreira, Joaquim J; Pinto, Fausto J.; Caldeira, DanielOBJECTIVE: Despite the progression of treatments over decades, heart failure (HF) is a disease with high morbidity, mortality and economic burden. Influenza infection is an important trigger for cardiovascular (CV) events, including HF. Influenza vaccination has been seen to reduce the risk of CV mortality in patients with coronary disease, but the effect in patients with HF is still unclear. Therefore, we cond...
The association of influenza infection and vaccine with myocardial infarction: ...
Caldeira, Daniel; Rodrigues, Bárbara Sucena; David, Cláudio; Costa, João; Pinto, Fausto J.; Ferreira, Joaquim JIntroduction: Influenza vaccination may be beneficial in coronary disease patients; however the infection and vaccination are associated with acute inflammation, a trigger of cardiovascular events. We aimed to review the risk of myocardial infarction (MI) associated with Influenza infection and the safety of vaccination in self-controlled case series (SCCS).Methods: We performed a systematic review with meta-an...