2 documents found, page 1 of 1
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor s...
Tanqueiro, Sara; Mouro, Francisco; Ferreira, Catarina B.; Freitas, Céline; Fonseca-Gomes, João; Simões Do Couto, Frederico; Sebastião, Ana MBackground: Cognitive deficits profoundly impact on the quality of life of patients with schizophrenia. Alterations in brain derived neurotrophic factor (BDNF) signalling, which regulates synaptic function through the activation of full-length tropomyosin-related kinase B receptors (TrkB-FL), are implicated in the aetiology of schizophrenia, as is N-methyl-D-aspartate receptor (NMDA-R) hypofunction. However, wh...
Chronic, intermittent treatment with a cannabinoid receptor agonist impairs rec...
Mouro, Francisco; Ribeiro, Joaquim A.; Sebastião, Ana M; Dawson, NeilElucidating how cannabinoids affect brain function is instrumental for the development of therapeutic tools aiming to mitigate 'on target' side effects of cannabinoid-based therapies. A single treatment with the cannabinoid receptor agonist, WIN 55,212-2, disrupts recognition memory in mice. Here, we evaluate how prolonged, intermittent (30 days) exposure to WIN 55,212-2 (1 mg/kg) alters recognition memory and ...