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Changes in Surgical Revascularization Strategy After Fractional Flow Reserve

Fournier, S; Toth, G; De Bruyne, B; Kala, P; Ribichini, F; Casselman, F; Ramos, R; Piroth, Z; Piccoli, A; Penicka, M; Mates, M; Nemec, P; Van Praet, F

Aims: In the randomized GRAFFITI trial, surgeons drew their strategy based on coronary angiography. When patients were randomized to fractional flow reserve (FFR)-guidance, surgeons were informed of the FFR values and asked to redraw their strategy. The aim of this study was to investigate the changes induced by FFR knowledge. Methods and results: The intended and performed strategy (before and after FFR) were ...


Study Design of the Graft Patency After FFR-Guided Versus Angiography-Guided CA...

Toth, GG; De Bruyne, B; Kala, P; Ribichini, FL; Casselman, F; Ramos, R; Piroth, Z; Fournier, S; Van Mieghem, C; Penicka, M; Mates, M; Van Praet, F

Clinical benefit of invasive functionally guided revascularization has been mostly investigated and proven for percutaneous coronary intervention. It has never been prospectively evaluated whether a systematic fractional flow reserve (FFR) assessment is also beneficial in guiding coronary artery bypass graft surgery (CABG). The objective of the GRAft patency after FFR-guided versus angiography-guIded CABG (GRAF...


Continuum of Vasodilator Stress From Rest to Contrast Medium to Adenosine Hyper...

Johnson, N; Jeremias, A; Zimmermann, F; Adjedj, J; Witt, N; Hennigan, B; Koo, B; Maehara, A; Matsumura, M; Barbato, E; Esposito, G; Trimarco, B

OBJECTIVES: This study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) ≤0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). BACKGROUND: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved wit...


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