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Kinetics of paraquat in the isolated rat lung: Influence of sodium depletion
Dinis Oliveira, RJ; De Jesus Valle, MJD; Bastos, ML; Carvalho, F; Sanchez S N NavarroParaquat accumulates in the lung through a characteristic polyamine uptake system. It has been previously shown that paraquat uptake can be significantly prevented if extracellular sodium (Na+) is reduced, although the available data correspond to experiments performed using tissue slices or incubated cells. This type of in vitro study fails to give information on the actual behaviour occurring in vivo since th...
Date: 2006
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Origin: Repositório Aberto da Universidade do Porto