2 documents found, page 1 of 1
Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental p...
Adao, R; Mendes Ferreira, P; Maia Rocha, C; Santos Ribeiro, D; Rodrigues, PG; Vidal Meireles, A; Monteiro Pinto, C; Pimentel, LD; Falcao Pires, IWe have previously shown that treatment with recombinant human neuregulin-1 (rhNRG-1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)-induced animal model, by decreasing pulmonary arterial remodelling and endothelial dysfunction, as well as by restoring right ventricular (RV) function. Additionally, rhNRG-1 treatment showed direct myocardial anti-remodelling effects in a model of pressur...
Update on pathophysiology and preventive strategies of anthracycline-induced ca...
Corremans, R; Adao, R; De Keulenaer, GW; Leite Moreira, AF; Brás-Silva CAnthracycline chemotherapy has a prominent role in treating many forms of cancer. Unfortunately, cardiotoxic side effects represent a serious limitation to their use, with doxorubicin being the leading drug of the group. Indeed, anthracycline-induced cardiomyopathy is an important public health concern because it may not be detected for many years and remains a lifelong threat. Even after decades of investigati...