2 documents found, page 1 of 1
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chem...
De Marchi, Pedro; Melendez, Matias E.; Laus, Ana C.; Kuhlmann, Pamela A.; de Carvalho, Ana Carolina; Arantes, Lidia Maria R.B.; Evangelista, Adriane F.Made available in DSpace on 2022-04-28T19:27:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This...
Mutational profle of Brazilian lung adenocarcinoma unveils association of EGFR ...
Leal, Letícia Ferro; Paula, Flávia Escremim de; De Marchi, Pedro; Viana, Luciano de Souza; Pinto, Gustavo Dix Junqueira; Carlos, Carolina DiasLung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicop...