26 documents found, page 1 of 3
COVID-19 vaccinations: summary guidance for Cancer patients in 28Languages: bre...
Mauri, Davide; Kamposioras, Konstantinos; Tsali, Lampriani; Dambrosio, Mario; De Bari, Berardino; Hindi, Nadia; Salembier, Carl; Nixon, JoannaBackground: Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalitie...
49P Impact of nutritional factors in response and survival of patients with ges...
Roque Perez, K.; Galvez Nino, M.A.; Castro, M.W.; Vallejos, H.D.; Ruiz, R.E.; Valdiviezo Lama, N.I.; Coanqui Gonzales, O.; Olivera, M.; Perez, J.Gestational trophoblastic neoplasia (GTN) is a rare tumor with an excellent prognosis. Despite the International Federation of Gynecology and Obstetrics (FIGO) risk score, other factors that may influence survival remain unknown.
BARX2/FOXA1/HK2 axis promotes lung adenocarcinoma progression and energy metabo...
Xie, Kai; Feng, Jian; Fan, Dingwei; Wang, Shi; Luo, Jing; Ren, Zhijian; Zheng, Chao; Diao, Yifei; De Mello, Ramon Andrade; Tavolari, SimonaBackground: Metabolic reprogramming is an emerging cancer feature that has recently drawn special attention since it promotes tumor cell growth and proliferation. However, the mechanism of the Warburg effect is still largely unknown. This research aimed to reveal the effects of BarH-like homeobox 2 (BARX2) in regulating tumor progression and glucose metabolism in lung adenocarcinoma (LUAD).Methods: Expression o...
Cutaneous soft tissue sarcomas: survival-related factors
Gkantaifi, Areti; Diamantis, Alexandros; Mauri, Davide; Nixon, Ioanna; Kyriazoglou, Anastassios; Baloyiannis, Ioannis; Tsoukalas, NikolaosCutaneous sarcomas are a heterogeneous group of rare mesenchymal neoplasms representing less than 1% of malignant tumors. Histology report remains the cornerstone for the diagnosis of these tumors. The most important clinicopathologic parameters related to prognosis include larger tumor size, high mitotic index, head and neck location, p53 mutations, depth of infiltration and histological grade, vascular and pe...
CRISPR-based strategies in infectious disease diagnosis and therapy
Binnie, Alexandra; Fernandes, Emanuel; Almeida‑Lousada, Helder; De Mello, Ramon Andrade; Castelo-Branco, PedroCRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called "molecular scissors" enable precise gene editing with a low error rate. However, CRISPR systems can also be targeted against pathogenic DNA or RNA sequences. This potential i...
Mutations associated with no durable clinical benefit to immune checkpoint bloc...
Zhu, Guangsheng; Ren, Dian; Lei, Xi; Shi, Ruifeng; Zhu, Shuai; Zhou, Ning; Zu, Lingling; De Mello, Ramon Andrade; Chen, Jun; XU, Song(1) Background: The immune checkpoint blockade (ICB) has shown promising efficacy in non-small-cell lung cancer (NSCLC) patients with significant clinical benefits and durable responses, but the overall response rate to ICBs is only 20%. The lack of responsiveness to ICBs is currently a central problem in cancer immunotherapy. (2) Methods: Four public cohorts comprising 2986 patients with NSCLC were included in...
Screening for colorectal cancer leading into a new decade: the “Roaring ‘20s” f...
Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara Maria Ventura; Price, Aryeh J.; De Mello, Ramon Andrade; Marreiros, AnaColorectal cancer (CRC) has an important bearing (top five) on cancer incidence and mortality in the world. The etiology of sporadic CRC is related to the accumulation of genetic and epigenetic alterations that result in the appearance of cancer hallmarks such as abnormal proliferation, evasion of immune destruction, resistance to apoptosis, replicative immortality, and others, contributing to cancer promotion,...
New target therapies in advanced non-small cell lung cancer: a review of the li...
De Mello, Ramon Andrade; Neves, Nathália Moisés; Tadokoro, Hakaru; Amaral, Giovanna Araújo; Castelo-Branco, Pedro; Zia, Victor André de AlmeidaLung cancer (LC) is the most common neoplasm worldwide, and 85% of these tumors are classified as non-small cell lung cancer (NSCLC). LC treatment was initially restricted to cytotoxic chemotherapy-platinum compounds associated with 3rd generation cytotoxic agents (paclitaxel, gemcitabine, pemetrexed) and, more recently, with monoclonal antibodies (bevacizumab, ramucirumab). Advancements in treatment are correl...
Current and future aspects of TIM-3 as biomarker or as potential targeted in no...
De Mello, Ramon Andrade; Zhu, Jin-Hui; Iavelberg, Jairo; Potim, Artur Henrique; Simonetti, Débora; Silva Jr, José Antônio; Castelo-Branco, PedroLung cancer is an aggressive disease with a high rate of mortality (1). Non-small cell lung cancer (NSCLC) constitutes approximately 85% of all histology types (2). In the 1990’s, chemotherapy was the standard of care for the treatment of metastatic NSCLC (3). Since 2005, targeted therapies have emerged as a new cornerstone in the treatment of NSCLC. These include epidermal growth factor receptor tyrosine kinas...
Synthesis of recommendations from 25 countries and 31 oncology societies: how t...
Kamposioras, Konstantinos; Mauri, Davide; Papadimitriou, Konstantinos; Anthoney, Alan; Hindi, Nadia; Petricevic, Branka; Dambrosio, MarioIntroduction Pandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak. Methods We did an international online search in twenty five countries that ha...