5 documents found, page 1 of 1
PREPARE: protocol for a stepped wedge trial to evaluate whether a risk stratifi...
Bastos Dias, Marcos Augusto; De Oliveira, Leandro [UNESP]; Jeyabalan, Arundhanthi; Payne, Beth; Redman, Christopher W.; Magee, Laura; Poston, LucillaMade available in DSpace on 2020-12-10T19:37:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10-07; Bill & Melinda Gates Foundation; Background Preeclampsia (PE) is a major cause of short and long-term morbidity for affected infants, including consequences of fetal growth restriction and iatrogenic prematurity. In Brazil, this is a special problem as PE accounts for 18% of preterm births (PTB). In the...
Creating biobanks in low and middle-income countries to improve knowledge - The...
De Oliveira, Leandro [UNESP]; Bastos Dias, Marcos Augusto; Jeyabalan, Arundhanthi; Payne, Beth; Redman, Christopher W.; Magee, Laura; Poston, LucillaMade available in DSpace on 2018-11-26T17:55:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-07-01; Bill & Melinda Gates Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The Millennium Development Goal 5, a project signed in 2000, intended to improve maternal health and reduce maternal mortality by 75% by 2015. Despite all efforts, little progress has been achieved in ...
Association between Placental Lesions, Cytokines and Angiogenic Factors in Preg...
Weel, Ingrid C. [UNESP]; Baergen, Rebecca N.; Romao-Veiga, Mariana [UNESP]; Borges, Vera T. [UNESP]; Ribeiro, Vanessa R. [UNESP]; Witkin, Steven S.Made available in DSpace on 2018-11-26T16:40:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-06-17; Preeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental l...
Relationship between hypoxia and downstream pathogenic pathways in preeclampsia
Korkes, Henri Augusto; De Oliveira, Leandro [UNESP]; Sass, Nelson; Salahuddin, Saira; Karumanchi, S. Ananth; Rajakumar, AugustineMade available in DSpace on 2018-11-26T17:34:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; Defects in angiogenesis and mitochondrial function in the placenta contribute to the pathogenesis of preeclampsia; however upstream regulators of these pathways are not known. It has been argued that placental hypoxia secondary to abnormal spiral artery remodeling may play a causal role in the angiogeni...
Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in ...
Nunes, Priscila Rezeck [UNESP]; Peracoli, Maria Terezinha Serrao [UNESP]; Romao-Veiga, Mariana [UNESP]; Matias, Mariana Leticia [UNESP]Made available in DSpace on 2018-12-11T17:21:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01; Background: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine produ...