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Methylation analysis of Klebsiella pneumoniae from Portuguese hospitals

Spadar, Anton; Perdigão, João; Phelan, Jody; Charleston, James; Modesto, Ana; Elias, Rita; De Sessions, Paola; Hibberd, Martin L.; Campino, Susana

Klebsiella pneumoniae is an important nosocomial infectious agent with a high antimicrobial resistance (AMR) burden. The application of long read sequencing technologies is providing insights into bacterial chromosomal and putative extra-chromosomal genetic elements (PEGEs) associated with AMR, but also epigenetic DNA methylation, which is thought to play a role in cleavage of foreign DNA and expression regulat...

Date: 2021   |   Origin: Repositório da Universidade de Lisboa
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