26 documents found, page 1 of 3
Comparing international guidelines for the remission of hypertension after bari...
Dias, Carina Vieira; Silva, Ana Lúcia; Dias, Joana; Cardoso, Paulo; Castanheira, Rute; Fernandes, Andreia; Nunes, Filipa; Sanai, Tina; Sanchez, MercedesBackground/Objectives: Obesity remains a global health concern and is associated with increased risk of type 2 diabetes, hypertension, and cardiovascular disease overall. Dissimilar hypertension guidelines are available for clinicians, namely those prepared by the American Heart Association (AHA) and the European Society of Cardiology (ESC), which may lead to distinctive appreciation of health outcomes of patie...
Editorial: advancing cancer therapy: innovative strategies targeting immune eva...
Teotónio Fernandes, Mónica Alexandra; De Sousa-Coelho, Ana Luísa; Méndez-Lucas, AndrésCancer remains one of the leading causes of death worldwide, with both incidence and mortality continuing to rise despite advances in diagnosis and treatment (1). While early-stage cancers often respond to conventional therapies, advanced and recurrent tumors frequently develop resistance, limiting long-term therapeutic efficacy (2).Two fundamental hallmarks of cancer, immune evasion and metabolic reprogramming...
Advancing glioblastoma research with innovative brain organoid-based models
Dias Correia, Cátia; Calado, Sofia; Matos, Alexandra; Oleiro Esteves, Filipa Alexandra; De Sousa-Coelho, Ana Luísa; Campinho, Marco AntónioGlioblastoma (GBM) is a relatively rare but highly aggressive form of brain cancer characterized by rapid growth, invasiveness, and resistance to standard therapies. Despite significant progress in understanding its molecular and cellular mechanisms, GBM remains one of the most challenging cancers to treat due to its high heterogeneity and complex tumor microenvironment. To address these obstacles, researchers ...
Potential impact of metabolic syndrome control on cardiovascular risk in elderl...
Nascimento, Tânia; Estêvão, Maria Dulce da Mota Antunes de Oliveira; Gonçalves, Adriana; Pinto, Ezequiel; De Sousa-Coelho, Ana LuísaMetabolic syndrome (MS), a complex pathology with features like abnormal body fat distribution, insulin resistance, and dyslipidaemia, contributes to higher cardiovascular (CV) risk. A cross-sectional study including 87 individuals assessed CV risk score in elderly patients with type 2 diabetes and MS in Algarve, Portugal. The 10-year CV risk score was estimated using the ADVANCE risk score calculator. The redu...
Preface: VII Poster Sunset Session—ESSUAlg 2024
De Sousa-Coelho, Ana Luísa; Teotónio Fernandes, Mónica Alexandra; Estêvão, Maria Dulce da Mota Antunes de Oliveira; Braz, Luis; Nascimento, TâniaThe event “Poster Sunset Session” began in 2017 at the School of Health of the University of Algarve (ESSUAlg), bringing the premise that scientific knowledge depends on research and critical analysis and that the exchange of ideas and information is an essential part of the continuous development process. This event was conceptualized and prepared by professors of the Pharmacy Department at ESSUAlg. The idea o...
Statement of Peer Review
De Sousa-Coelho, Ana Luísa; Teotónio Fernandes, Mónica Alexandra; Estêvão, Maria Dulce da Mota Antunes de OliveiraIn submitting conference proceedings to Proceedings, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors. The reviews were conducted by expert referees, and to the professional and scientific standards expected of a proceedings journal.
Remission of polypharmacy in patients with diabetes after obesity surgery
Dias, Joana; Cardoso, Paulo; Sanchez, Mercedes; Maia-Teixeira, João; De Sousa-Coelho, Ana LuísaIntroduction: Obesity contributes to increased risk of developing comorbidities that require polypharmacy (taking ≥5 medicines) [1], namely type 2 diabetes (T2D) [2], increasing the risk of drug-related problems. Bariatric surgery (BS) has emerged as the most effective treatment for obesity and T2D remission [3–5]. Objective: The goal of this study was to evaluate the impact of BS in the remission of polypharma...
AHA vs ESC guidelines at the race for hypertension remission after obesity surg...
Dias, Carina; Dias, Joana; Silva, Ana Lúcia; Cardoso, Paulo; Castanheira, Rute; Sanchez, Mercedes; Maia-Teixeira, João; De Sousa-Coelho, Ana LuísaBackground: Obesity is associated with increased risk of hypertension. Dissimilar hypertension guidelines are available for clinicians, namely prepared by the American Heart Association (AHA) and the European Society of Cardiology (ESC) [1,2]. While AHA guidelines consider pharmacological treatment to all patients when blood pressure (BP) values ≥140/90 mmHg, ESC recommends it that only consider pharmacological...
Repurposing therapeutic drugs complexed to Vanadium in Cancer
De Sousa-Coelho, Ana Luísa; Fraqueza, Gil; Aureliano, M.Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs,...
Biological consequences of Vanadium effects on formation of reactive oxygen spe...
Aureliano, Manuel; De Sousa-Coelho, Ana Luísa; Dolan, Connor C.; Roess, Deborah A.; Crans, Debbie C.Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions...