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Variation in very preterm extrauterine growth in a European multicountry cohort

El Rafei, R; Jarreau, PH; Norman, M; Maier, RF; Barros, H; Reempts, PV; Pedersen, P; Cuttini, M; Zeitlin, J; EPICE Research Group

Objective Extrauterine growth restriction (EUGR) among very preterm infants is related to poor neurodevelopment, but lack of consensus on EUGR measurement constrains international research. Our aim was to compare EUGR prevalence in a European very preterm cohort using commonly used measures. Design Population-based observational study. Setting 19 regions in 11 European countries. Patients 6792 very preterm infa...


Managing mother’s own milk for very preterm infants in neonatal units in 11 Eur...

Rodrigues, C; Zeitlin, J; Wilson, E; Toome, L; Cuttini, M; Maier, RF; Pierrat, V; Barros, H; EPICE Research Group

Feeding with human milk has been recognised as an essential component of newborn care and is especially important for infants born very preterm (VPT, below 32 weeks of gestation) who face higher risks of adverse outcomes. WHO recommends that infants who cannot be fed mother's own milk (MOM) should receive donor human milk. Direct feeding at the breast takes time to establish after VPT birth and procedures are r...


Association between postnatal growth and neurodevelopmental impairment by sex a...

El Rafei, R; Jarreau, PH; Norman, M; Maier, RF; Barros, H; Van Reempts, P; Pedersen, P; Cuttini, M; Costa, R; Zemlin, M; Draper, ES; Zeitlin, J

Background & aims: Extra-uterine growth restriction (EUGR) is common among very preterm (VPT) infants and has been associated with impaired neurodevelopment. Some research suggests that adverse effects of EUGR may be more severe in boys. We investigated EUGR and neurodevelopment at 2 years of corrected age (CA) by sex in a VPT birth cohort. Methods: Data come from a population-based cohort of children born <32 ...


Postnatal Corticosteroids Policy for Very Preterm Infants and Bronchopulmonary ...

Nuytten, A; Behal, H; Duhamel, A; Jarreau, PH; Torchin, H; Milligan, D; Maier, RF; Zemlin, M; Zeitlin, J; Truffert, P; EPICE Research Group

Introduction: Postnatal corticosteroids (PNC) are effective for reducing bronchopulmonary dysplasia (BPD) in very preterm neonates but are associated with adverse effects including an increased risk of cerebral palsy. PNC use in Europe is heterogeneous across regions. This study aimed to assess whether European neonatal intensive care units (NICUs) with a low use of PNC or an explicit policy to reduce PNC use h...


Mode of delivery and mortality and morbidity for very preterm singleton infants...

Schmidt, S; Norman, M; Misselwitz, B; Piedvache, A; Huusom, LD; Varendi, H; Barros, H; Cammu, H; Blondel, B; Dudenhausen, J; Zeitlin, J; Weber, T

Objective Caesarean section (CS) may reduce mortality and morbidity for very preterm breech infants, but evidence is inconclusive. We evaluated neonatal outcomes for singleton breech infants by mode of delivery in a European cohort. Study design Data come from the EPICE population-based cohort of very preterm births in 19 regions in 11 European countries (7770 live births). The study population was singleton sp...


Low breastfeeding continuation to 6 months for very preterm infants: A European...

Bonnet, C; Blondel, B; Piedvache, A; Wilson, E; Bonamy, AE; Gortner, L; Rodrigues, C; van Heijst, A; Draper, ES; Cuttini, M; Zeitlin, J

Breastfeeding confers multiple benefits for the health and development of very preterm infants, but there is scarce information on the duration of breastfeeding after discharge from the neonatal intensive care unit (NICU). We used data from the Effective Perinatal Intensive Care in Europe population‐based cohort of births below 32 weeks of gestation in 11 European countries in 2011–2012 to investigate breastfee...


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