4 documents found, page 1 of 1
Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromo...
Martins, Thaís Viana Fialho; Zeraik, Ana Eliza; Alves, Natália Oliveira; Oliveira, Leandro Licursi de; Mendes, Tiago Antônio de OliveiraLeishmania infantum chagasi is an intracellular protozoan parasite responsible for visceral leishmaniasis, a fatal disease in humans. Heparin-binding proteins (HBPs) are proteins that bind to carbohydrates present in glycoproteins or glycolipids. Evidence suggests that HBPs present on Leishmania surface participate in the adhesion and invasion of parasites to tissues of both invertebrate and vertebrate hosts. I...
Microexon gene transcriptional profiles and evolution provide insights into blo...
Li, Xiao Hong; DeMarco, Ricardo; Neves, Leandro Xavier; James, Sally R.; Newling, Katherine; Ashton, Peter D.; Cao, Jian Ping; Wilson, R. AlanAdult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonic...
The schistosome eesophageal gland : initiator of blood processing.
Li, Xiao Hong; Borges, William de Castro; Manuel, Sophie J. Parker; Vance, Gillian M.; DeMarco, Ricardo; Neves, Leandro Xavier; Evans, Garet J. O.Background: Although the ultrastructure of the schistosome esophageal gland was described .35 years ago, its role in the processing of ingested blood has never been established. The current study was prompted by our identification of MEG-4.1 expression in the gland and the observation of erythrocyte uncoating in the posterior esophagus. Methodology/Principal Findings: The salient feature of the posterior esopha...
Influence of ecto-nucleoside triphosphate diphosphohydrolase activity on Trypan...
Santos, Ramon de Freitas; Pôssa, Marcela Auxiliadora Souza; Bastos, Matheus Silva e; Guedes, Paulo Marcos da Matta; Almeida, Márcia Rogéria deBackground: The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when most patients are diagnosed. There is a clear necessity to develop new drugs and strategies for the control and treatment of Chagas disease. Recent papers have suggested the ecto-nucleotidases (from CD39 family) from pathogenic agents as importa...