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Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multic...

Pirnay, Jean-Paul; Djebara, Sarah; Steurs, Griet; Griselain, Johann; Cochez, Christel; De Soir, Steven; Glonti, Tea; Spiessens, An; Vanden Berghe, Emily

In contrast to the many reports of successful real-world cases of personalized bacteriophage therapy (BT), randomized controlled trials of non-personalized bacteriophage products have not produced the expected results. Here we present the outcomes of a retrospective observational analysis of the first 100 consecutive cases of personalized BT of difficult-to-treat infections facilitated by a Belgian consortium i...


Profiling bacteria in the lungs of patients with severe influenza versus COVID-...

Feys, Simon; Cardinali-Benigni, Martina; Lauwers, Hanne Moon; Jacobs, Cato; Stevaert, Annelies; Gonçalves, Samuel M; Cunha, Cristina; Debaveye, Yves

Rationale: The influence of the lung bacterial microbiome, including potential pathogens, in patients with influenza-associated pulmonary aspergillosis (IAPA) or coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) has yet to be explored. Objectives: To explore the composition of the lung bacterial microbiome and its association with viral and fungal infection, immunity, and outcome in sever...


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