19 documents found, page 1 of 2
Persistent interstitial lung abnormalities in post-COVID-19 patients: a case se...
Lago,Vanessa Carvalho; Prudente,Robson Aparecido; Luzia,Dayane Araujo; Franco,Estefânia Thomé; Cezare,Talita Jacon; Peralta,AmandaAbstract A new concept of multisystem disease has emerged as a long-term condition following mild-severe COVID-19 infection. The main symptoms of this affection are breathlessness, chest pain, and fatigue. We present here the clinical case of four COVID-19 patients during hospitalization and 60 days after hospital discharge. Physiological impairment of all patients was assessed by spirometry, dyspnea score, art...
Brazilian guidelines for the pharmacological treatment of idiopathic pulmonary ...
Baddini-Martinez,José; Ferreira,Juliana; Tanni,Suzana; Alves,Luis Renato; Cabral Junior,Benedito Francisco; Carvalho,Carlos Roberto RibeiroABSTRACT Idiopathic pulmonary fibrosis (IPF) is a form of chronic interstitial lung disease of unknown cause, which predominantly affects elderly men who are current or former smokers. Even though it is an uncommon disease, it is of great importance because of its severity and poor prognosis. In recent decades, several pharmacological treatment modalities have been investigated for the treatment of this disease...
Segurança e tolerabilidade de Nintedanibe em pacientes com fibrose pulmonar idi...
Pereira,Carlos Alberto de Castro; Baddini-Martinez,José Antonio; Baldi,Bruno Guedes; Jezler,Sérgio Fernandes de Oliveira; Rubin,Adalberto SperbRESUMO Objetivo Ensaios clínicos mostraram que 150 mg de Nintedanibe duas vezes ao dia reduzem a progressão da doença em pacientes com Fibrose Pulmonar Idiopática (FPI), com um perfil de efeitos adversos que é controlável para a maioria dos pacientes. Antes da aprovação do Nintedanibe como tratamento para a FPI no Brasil, um Programa de Acesso Expandido (PEA) foi iniciado para fornecer acesso precoce ao tratame...
Characterization and outcomes of pulmonary alveolar proteinosis in Brazil: a ca...
Athayde,Rodolfo Augusto Bacelar de; Arimura,Fábio Eiji; Kairalla,Ronaldo Adib; Carvalho,Carlos Roberto Ribeiro; Baldi,Bruno GuedesABSTRACT Objective: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the alveolar accumulation of surfactant, which is composed of proteins and lipids. PAP is caused by a deficit of macrophage activity, for which the main treatment is whole-lung lavage (WLL). We report the experience at a referral center for PAP in Brazil. Methods: This was a retrospective study involving patients with P...
Diffuse cystic lung diseases: differential diagnosis
Baldi,Bruno Guedes; Carvalho,Carlos Roberto Ribeiro; Dias,Olívia Meira; Marchiori,Edson; Hochhegger,BrunoABSTRACT Diffuse cystic lung diseases are characterized by cysts in more than one lung lobe, the cysts originating from various mechanisms, including the expansion of the distal airspaces due to airway obstruction, necrosis of the airway walls, and parenchymal destruction. The progression of these diseases is variable. One essential tool in the evaluation of these diseases is HRCT, because it improves the chara...
Lung-dominant connective tissue disease among patients with interstitial lung d...
Pereira,Daniel Antunes Silva; Dias,Olívia Meira; Almeida,Guilherme Eler de; Araujo,Mariana Sponholz; Kawano-Dourado,Letícia Barbosa; Baldi,Bruno GuedesOBJECTIVE: To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD). METHODS: This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (≥ 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CTD). RESULTS: Of the 1,998 pat...
Use of sirolimus in the treatment of lymphangioleiomyomatosis: favorable respon...
Freitas,Carolina Salim Gonçalves; Baldi,Bruno Guedes; Araújo,Mariana Sponholz; Heiden,Glaucia Itamaro; Kairalla,Ronaldo AdibOBJECTIVE: Lymphangioleiomyomatosis (LAM) is a rare disease that is currently considered a low-grade neoplasm with metastatic potential and variable progression. Mammalian target of rapamycin (mTOR) inhibitors, such as sirolimus and everolimus, have recently become a treatment option for LAM patients, especially those with extrapulmonary manifestations. The objective of the present study was to describe a case ...
Update on diagnosis and treatment of idiopathic pulmonary fibrosis
Baddini-Martinez,José; Baldi,Bruno Guedes; Costa,Cláudia Henrique da; Jezler,Sérgio; Lima,Mariana Silva; Rufino,RogérioIdiopathic pulmonary fibrosis is a type of chronic fibrosing interstitial pneumonia, of unknown etiology, which is associated with a progressive decrease in pulmonary function and with high mortality rates. Interest in and knowledge of this disorder have grown substantially in recent years. In this review article, we broadly discuss distinct aspects related to the diagnosis and treatment of idiopathic pulmonary...
Adalimumab-induced acute interstitial lung disease in a patient with rheumatoid...
Dias,Olivia Meira; Pereira,Daniel Antunes Silva; Baldi,Bruno Guedes; Costa,Andre Nathan; Athanazio,Rodrigo Abensur; Kairalla,Ronaldo AdibThe use of immunobiological agents for the treatment of autoimmune diseases is increasing in medical practice. Anti-TNF therapies have been increasingly used in refractory autoimmune diseases, especially rheumatoid arthritis, with promising results. However, the use of such therapies has been associated with an increased risk of developing other autoimmune diseases. In addition, the use of anti-TNF agents can c...
Combined pulmonary fibrosis and emphysema: an increasingly recognized condition
Dias,Olívia Meira; Baldi,Bruno Guedes; Costa,André Nathan; Carvalho,Carlos Roberto RibeiroCombined pulmonary fibrosis and emphysema (CPFE) has been increasingly recognized in the literature. Patients with CPFE are usually heavy smokers or former smokers with concomitant lower lobe fibrosis and upper lobe emphysema on chest HRCT scans. They commonly present with severe breathlessness and low DLCO, despite spirometry showing relatively preserved lung volumes. Moderate to severe pulmonary arterial hype...