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Comparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Rati...

Lee, J; Choi, K; Koo, B; Dehbi, H; Doh, J; Nam, C; Baptista, SB, et al.; The DEFINE-FLAIR Trial Investigators

IMPORTANCE: Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated. OBJECTIVE: To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and wi...


Clinical Events After Deferral of LAD Revascularization Following Physiological...

Sen, S; Ahmad, Y; Dehbi, H; Howard, J; Iglesias, J; Al-Lamee, R; Baptista, SB, et al.

BACKGROUND: Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physio...


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