545 documents found, page 1 of 55
Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towar...
Barbosa, Tiago; Morais, Stephanie L.; Carvalho, Renato; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Delerue-Matos, CristinaAnticoagulants, including warfarin, are often administered to patients who are exhibiting early symptoms of thromboembolic episodes or who have already experienced such episodes. However, warfarin has a limited therapeutic index and might cause bleeding and other clinical problems. Warfarin inhibits the vitamin K epoxide reductase complex subunit 1 (VKORC1), an enzyme essential for activating vitamin K, in the ...
Screening for microplastics in agricultural soils: Applying green chemistry pri...
Rede, Diana; Vilarinho, Rui; Delerue-Matos, Cristina; Moreira, Joaquim Agostinho; Fernandes, Virgínia Cruz; Fernandes, VirgíniaIn recent years, microplastic (MP) pollution has garnered significant attention owing to its ability to permeate various ecosystems, including soil. These particles can infiltrate the environment, either directly or through the degradation of larger plastic items. Despite growing concerns, standardized methods for quantification are still lacking. This study aimed to screen for the presence of MPs in agricultur...
Optimized extraction protocols for bioactive antioxidants from commercial seawe...
Santos, Francisca; Soares, Cristina; Morais, Stephanie L.; Neves, Cátia; Grosso, Clara; Ramalhosa, Maria João; Vieira, Mónica; Delerue-Matos, CristinaThis study aimed to optimize the extraction conditions for a valuable source of antioxidants: seaweed. Therefore, ten seaweed samples were subjected to a solid–liquid extraction (SLE), where the extraction conditions (biomass (g): solvent (mL) ratio, temperature, and time) were optimized using response surface methodology (RSM). The seaweeds were also subjected to subcritical water extraction (SWE) (140 and 190...
Unlocking the functional potential of Mesembryanthemum nodiflorum: Insights int...
Pinto, Diana; Vieira, Raquel; Teixeira, Filipa; Sut, Stefania; Vieira, Mónica; Salazar, Miguel; Delerue-Matos, Cristina; Dall’Acqua, StefanoMesembryanthemum nodiflorum, commonly known as slenderleaf iceplant, is an undervalued edible halophyte. The nutraceutical potential of M. nodiflorum was investigated in the current study by extracting bioactive compounds using ultrasound-assisted extraction (UAE) and assessing the influence of gastrointestinal digestion and intestinal permeability on their bioactive composition. The phenolic and flavonoid cont...
Improving honey authentication: Electrochemical genosensors for the detection o...
Morais, Stephanie; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Delerue-Matos, Cristina; Barroso, M. Fátima; Santos, MarleneMonofloral honeys, like heather honey, are a highly sought-after ingredient. However, food safety concerns have emerged due to the number of adulterated honeys found in the global market [1,2]. Thus, this work aimed to develop an electrochemical genosensor capable of detecting the residual DNA of Erica arborea (heather flower) in commercial honey samples. Analyzing public databases, a 98-mer E. arborea DNA-targ...
Unraveling the nutraceutical potential of Salicornia ramosissima by-product – i...
Pinto, Diana; Santos, Inês; Delerue-Matos, Cristina; Teixeira, Filipa; Sut, Stefania; Dall’Acqua, Stefano; Vieira, Mónica; Rodrigues, FranciscaSalicornia ramosissima by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates a...
Design of innovative electrochemical genosensors for honey fraud and quality de...
Morais, Stephanie L.; Castanheira, Michelle; Pereira, Eduarda; Santos, Marlene; Domingues, Valentina F.; Delerue-Matos, Cristina; Barroso, M. FátimaEnsuring food safety has become a concern for companies, consumers and the government alike, due to the increase of fraudulent and/or adulterated food products found in the global market [1,2]. Some common fraudulent strategies include mislabelling a product's geographical origin and blending it with lower-grade substances [3]. Among the frequently adulterated food products there is honey. Honey is a highly sou...
Influence of dispersant and surfactant on nZVI characterization by dynamic ligh...
Fernandes, Filipe Jorge; Oliveira, Ana Isabel; Delerue-Matos, Cristina; Grosso, Clara; Oliveira, Ana IsabelThe agrifood industries generate tremendous amounts of waste. The valorisation of these wastes is of the utmost importance. Here, spent coffee ground (SCG) and Cistus ladanifer L. leaf (CLL) post-distillation residues were used to prepare 50:50 (v/v) hydromethanolic extracts for green zero-valent iron nanoparticle (nZVI) production. Then, the nZVIs’ size, polydispersity index (PDI) and zeta potential (ZP) were ...
Brewing spent yeast as a sustainable solution for Tannin adsorption
Vieira, Elsa F.; Amaral, Tomás; Moreira, Jorge; Brandão, Tiago; Delerue-Matos, CristinaThis study explored the potential of brewing spent yeast (BSY) as an adsorbent for tannins from a chestnut shell extract (CS-tannin extract). The extract was obtained through an alkaline treatment (5% NaOH (v/v)) to recover cellulosic material from chestnut shells, which requires further valorisation. Various BSY treatments, including lyophilization, immobilization in calcium alginate beads, and alkaline and ac...
Culinary plant-based decoctions: A promising approach for combatting neurodegen...
Grosso, Clara; Martins, Rosário; Delerue-Matos, Cristina; Martins, RosarioThis study aimed to assess the effectiveness of nutritional therapy in preventing or treating neurodegenerative disorders. To achieve this, decoctions from 5 culinary plants - turmeric (Curcuma longa L.), rosemary (Salvia rosmarinus Spenn.), lemon basil (Ocimum basilicum L. var. citriodorum), spearmint (Mentha spicata L.) and winter savory (Satureja montana L.) - were evaluated for their ability to combat react...