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Polymyxin Acute Kidney Injury: a case of severe tubulopathy
Goldin,Lucas Alexandre de Mello; Silva,Leticia Nicoletti; Silva,Thiago Florencio da; Delfino,Vinicius Daher AlvaresAbstract Polymyxins are antibiotics developed in the 1950s. Polymyxin-induced neurotoxicity has been often described in medical literature. The same cannot be said of nephrotoxicity or tubulopathy in particular. This report describes the case of a patient prescribed polymyxin B to treat a surgical wound infection, which led to significant increases in fractional excretion of calcium, magnesium, and potassium an...
Hypoparathyroidism and Fahr’s syndrome: case series
Arruda,Anna Catarina Gatzk de; Guerra,Amanda Carolina Damasceno Zanuto; Pessoa,Carlos Henrique; Marquezine,Guilherme FigueiredoAbstract Hypoparathyroidism (HP) is a rare metabolic disorder and causes hypocalcemia because parathyroid hormone secretion is inadequate to mobilize calcium from bone and reabsorb calcium from kidney and gut. Anterior neck surgery is the most common cause of acquired HP and autoimmune HP is the next most common form in adults. The duration, severity, and rate of development of hypocalcemia determine the clinic...
Recommendations from the Brazilian Society of Nephrology regarding the use of c...
Abreu,Andrea Pio de; Moura Neto,José Andrade; Delfino,Vinicius Daher Alvares; Palma,Lilian Monteiro Pereira; Nascimento,Marcelo Mazza doABSTRACT These recommendations were created after the publication of informative note 3/2020- CGGAP/DESF/SAPS/MS, of April 4, 2020, in which the Brazilian Ministry of Health recommended the use of a cloth mask by the population, in public places. Taking into account the necessary prioritization of the provision of Personal Protective Equipment (PPE) for patients with suspected or confirmed disease, as well as f...
Covid-19 (Sars-Cov-2 Infection) Information for Patients with Predialytic Chron...
Delfino,Vinicius Daher Alvares; Nascimento,Marcelo Mazza do; Barros Neto,Jose de RezendeABSTRACT Patients with Chronic Kidney Disease are among those individuals at increased risk for developing more serious forms of Covid-19. This increased risk starts in the pre-dialysis phase of the disease. Providing useful information for these patients, in language that facilitates the understanding of the disease, can help nephrologists and other healthcare professionals to establish a more effective commun...
Vitamin D deficiency is not associated with increased oxidative stress in chron...
Matsumoto,Andressa Keiko; Maes,Michael; Michelin,Ana Paula; Soares,Abel Esteves; Semeão,Laura de Oliveira; Godeny,Paula; Venturini,DanielleAbstract Introduction: The progressive decline in 25-hydroxyvitamin D [25(OH)D] in chronic kidney disease (CKD) limits the kidney ability of synthesizing the vitamin. Vitamin D deficiency as defined by KDIGO (25(OH)D <20 ng/mL) is prevalent in CKD patients and associated to oxidative stress (OS). We studied a possible association between vitamin D deficiency and OS in pre-dialysis patients. Methods: A cross-sec...
Non-recovery of renal function is a strong independent risk factor associated w...
Santos,Reginaldo Passoni dos; Carvalho,Ariana Rodrigues da Silva; Peres,Luis Alberto Batista; Delfino,Vinicius Daher AlvaresABSTRACT Introduction: Acute kidney injury (AKI) is a recurrent complication in the intensive care unit (ICU) and is associated with negative outcomes. Objective: To investigate factors associated with mortality in critically ill AKI patients in a South Brazilian ICU. Methods: The study was observational retrospective involving AKI patients admitted to the ICU between January 2011 and December 2016 of at least ...
Renal histological findings in a patient with acute renal injury associated wit...
Martins,Julia Izadora da Silva; Bertoglio,Isabela Maria; Guerra,Amanda Carolina Damasceno Zanuto; Maioli,Mariana Espiga; Delfino,Vinicius Daher AlvaresABSTRACT Introduction: Purpura fulminans (PF) is a rapid progressive thrombotic disease in which hemorrhagic infarction of the skin and disseminated intravascular coagulation (DIC) occurs. It can potentially cause acute kidney injury (AKI). However, there is no description in the medical literature of renal histological findings of PF. Case report: A 20-year-old female patient, previously healthy, was admitted ...
Functional iron deficiency in patients on hemodialysis: prevalence, nutritional...
Plastina,Juliana Carvalho Romagnolli; Obara,Vitor Y.; Barbosa,Décio Sabbatini; Morimoto,Helena Kaminami; Reiche,Edna Maria Vissoci; Graciano,AndreaAbstract Introduction: Anemic patients with chronic kidney disease (CKD) can be divided into anemic patients without or with functional iron deficiency (FID). The increase in the number of cases of hemosiderosis in patients on hemodialysis (HD) attributed to excessive intravenous iron replacement has called for the investigation of the factors involved in the genesis of FID. Objectives: This study aimed to desc...
Upper gastrointestinal alterations in kidney transplant candidates
Homse Netto,João Pedro; Pinheiro,João Pedro Sant'Anna; Ferrari,Mariana Lopes; Soares,Mirella Tizziani; Silveira,Rogério Augusto GomesABSTRACT Introduction: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. Objectives: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant...
Reversal of uremic tumoral calcinosis by optimization of clinical treatment of ...
Maioli,Mariana Espiga; Delfino,Vinicius Daher Alvares; Guerra,Amanda Carolina Damasceno Zanuto; Kunii,Luiz Fernando; Frange,Raquel Ferreira NassarAbstract Tumoral calcinosis is an uncommon type of extraosseous calcification characterized by large rubbery or cystic masses containing calcium-phosphate deposits. The condition prevails in the periarticular tissue with preservation of osteoarticular structures. Elevated calcium-phosphorus products and severe secondary hyperparathyroidism are present in most patients with uremic tumoral calcionosis (UTC). Case...