6 documents found, page 1 of 1
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Caldeira Rosa, Paulo; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoPublisher Copyright: © 2025 by the authors.; Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. M...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
dos Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelThis research was funded by Fundacao para a Ciencia e Tecnologia Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT-MCTES) and Aga Khan Foundation (FCT/MCTES/Aga Khan, project no 330842553), by FCT/MCTES funding to H&TRC (UIDB/05608/2020, UIDP/05608/2020) and to GHTM IHMT NOVA (UID/04413/2020) and LA-REAL - LA/P/0117/2020.; Background Sickle Cell Anemia (SCA) is a monogenic disease, although its severity ...
Sickle Cell Disease and Gut Health
Delgadinho, Mariana; Ginete, Catarina; Santos, Brígida; de Vasconcelos, Jocelyne Neto; Arez, Ana Paula; Brito, MiguelFunding Information: This work was funded by the following grants: IPL/IDI&CA2022/ParasitSCD, FCT/Aga Khan (project no. 330842553), and FCT/MCTES (https://doi.org/10.54499/UIDB/05608/2020 and https://doi.org/10.54499/UIDP/05608/2020)-H&TRC. Author M.D. has received financial support from an FCT research fellowship UI/BD/150705/2020 (https://doi.org/10.54499/UI/BD/150705/2020). Publisher Copyright: © 2024 by the...
DNA methyltransferase expression (DNMT1, DNMT3a and DNMT3b) as a potential biom...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Varandas, Teresa; Nascimento, João; Henriques, José; Dutra-Medeiros, Marco; Delgadinho, MarianaFunding Information: This project was partially supported by an IDI&CA grant IPL/2021/DiffMeDiME_ESTeSL by H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa and by Retina Institute of Lisbon (IRL).; Purpose: DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of DN...
Gut microbiota profile of COVID-19 patients
Nobre, José Guilherme; Delgadinho, Mariana; Silva, Carina; Mendes, Joana; Mateus, Vanessa; Ribeiro, Edna; Costa, Diogo Alpuim; Lopes, MiguelFunding Information: The authors acknowledge financial support from Instituto Politécnico de Lisboa that supported this project with the grant Microcovid. This project was also partially supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020). Publisher Copyright: Copyright © 2022 Nobre, Delgadinho, Silva, Mendes, Mateus, Ribeiro, Costa, Lopes, Pedroso, Trigueiros, Rodrigues, de Sousa and Brito.; Backgroun...
Genetic modulation of anemia severity, hemolysis level, and hospitalization rat...
Germano, Isabel; Santos, Brígida; Delgadinho, Mariana; Ginete, Catarina; Lopes, Pedro; Arez, Ana Paula; Brito, Miguel; Faustino, PaulaBackground Sickle Cell Anemia (SCA) is a genetic disease caused by the c.20 A > T mutation in HBB gene, generally characterized by sickle erythrocytes, chronic hemolytic anemia, and vaso-occlusive events. This study aimed to investigate genetic modulators of anemia severity, chronic hemolytic rate, and clinical manifestations in pediatric SCA patients from Angola, where the disease is a severe public health pro...