8 documents found, page 1 of 1

The peptide secreted at the water to land transition in a model amphibian has a...

Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the develo...

The peptide secreted at the water to land transition in a model amphibian has a...

In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...

Caracterização de peptídeos bioativos das serpentes Bothrops atrox E B. moojeni...

Tese (doutorado) — Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Medicina Tropical, 2022.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).; Os estudos elaborados para conclusão dessa tese tiveram por objetivo avaliar os efeitos bioativos dos peptídeos sintéticos produzidos a partir dos estudos comparativos de atividade bactericida e leishmanicida de uma espé...

Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...

Snake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...

Synergistic and antibiofilm properties of ocellatin peptides against multidrug-...

Aim:To test ocellatin peptides (ocellatins-PT2-PT6) for antibacterial and antibiofilm activities and synergy with antibiotics against Pseudomonas aeruginosa. Materials & methods: Normal- and checkerboard-broth microdilution methods were used. Biofilm studies included microtiter plate-based assays and microscopic analysis by confocal laser scanning microscopy and atomic force microscopy. Results: Ocellatins were...

Angiogenesis in Schistosomiasis: contribution to cancer and disease

Angiogenesis in schistosomiasis: contribution to cancer and disease

Introdução: A schistosomose é uma Infeção associada a ovos de Schistosoma em tecidos. Os antigénios libertados pelo ovo estimulam uma reação granulomatosa envolvendo linfócitos, macrófagos e eosinófilos que resultam em doença clínica Schistosomose é considerada a segunda doença parasitária, a seguir à malária no mundo. Os seus agentes etiológlcos estão relacionados ao processo carcinogénico na bexiga e à fibros...

Angiogenesis in Schistosoma haematobium-associated urinary bladder cancer

Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood ve...