5 documents found, page 1 of 1
Co-axial hydrogel spinning for facile biofabrication of prostate cancer-like 3D...
Guimarães, Carlos Ferreira; Liu, Shiqin; Wang, Jie; Purcell, Emma; Ozedirne, Tugba; Ren, Tanchen; Aslan, Merve; Yin, Qingqing; Reis, R. L.Glandular cancers are amongst the most prevalent types of cancer, which can develop in many different organs, presenting challenges in their detection as well as high treatment variability and failure rates. For that purpose, anticancer drugs are commonly tested in cancer cell lines grown in 2D tissue culture on plastic dishes in vitro, or in animal models in vivo. However, 2D culture models diverge significant...
Engineering hydrogel-based biomedical photonics: design, fabrication, and appli...
Guimarães, Carlos F.; Ahmed, Rajib; Marques, A. P.; Reis, R. L.; Demirci, UtkanLight guiding and manipulation in photonics have become ubiquitous in events ranging from everyday communications to complex robotics and nanomedicine. The speed and sensitivity of lightâ matter interactions offer unprecedented advantages in biomedical optics, data transmission, photomedicine, and detection of multi-scale phenomena. Recently, hydrogels have emerged as a promising candidate for interfacing photo...
3DICE coding matrix multidirectional macro-architecture modulates cell organiza...
Canadas, Raphael Faustino; Costa, João Pedro Bebiano; Mao, Zhengwei; Gao, Changyou; Demirci, Utkan; Reis, R. L.; Marques, A. P.; Oliveira, J. M.Natural extracellular matrix governs cells providing biomechanical and biofunctional outstanding properties, despite being porous and mostly made of soft materials. Among organs, specific tissues present specialized macro-architectures. For instance, hepatic lobules present radial organization, while vascular sinusoids are branched from vertical veins, providing specific biofunctional features. Therefore, it is...
Emerging biofabrication approaches for gastrointestinal organoids towards patie...
Soto, Fernando; Guimarães, Carlos F.; Reis, R. L.; Franco, Walfre; Rizvi, Imran; Demirci, UtkanTissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-asse...
Biochemical gradients to generate 3D heterotypic-like tissues with isotropic an...
Canadas, Raphael Faustino; Ren, Tachen; Marques, A. P.; Oliveira, J. M.; Reis, R. L.; Demirci, UtkanAnisotropic 3D tissue interfaces with functional gradients found in nature are replicated in vitro for drug development and tissue engineering. Even though different fabrication techniques, based on material science engineering and microfluidics, are used to generate such microenvironments, mimicking the native tissue gradient is still a challenge. Here, the fabrication of 3D structures are described with linea...