15 documents found, page 1 of 2
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Issue 1 - "Update on adverse respiratory effects of outdoor air pollution" Part...
Sousa, A. C. M.; Pastorinho, M. R.; Masjedi, M. R.; Urrutia-Pereira, M.; Arrais, M.; Nunes, E.; To, T.; Ferreira, A. J.; Robalo-Cordeiro, C.Objective: To analyse the GARD perspective on the health effects of outdoor air pollution, and to synthesise the Portuguese epidemiological contribution to knowledge on its respiratory impact. Results: Ambient air pollution has deleterious respiratory effects which are more apparent in larger, densely populated and industrialised countries, such as Canada, Iran, Brazil and Portugal, but it also affects people l...
Issue 1 - “Update on adverse respiratory effects of outdoor air pollution” Part...
Sousa, A.C.; Pastorinho, M.R.; Masjedi, M.R.; Urrutia-Pereira, M.; Arrais, M.; Nunes, E.; To, T.; Ferreira, A.J.; Robalo-Cordeiro, C.; Borrego, C.Objective: To analyse the GARD perspective on the health effects of outdoor air pollution, and to synthesise the Portuguese epidemiological contribution to knowledge on its respiratory impact. Results: Ambient air pollution has deleterious respiratory effects which are more apparent in larger, densely populated and industrialised countries, such as Canada, Iran, Brazil and Portugal, but it also affects people l...
As cheias na construção e evolução da Lezíria do Tejo: síntese de dois projetos
Azevêdo, T. M.; Ramos Pereira, A.; Nunes, E.This article presents a summary of the final results of two projects funded by the Foundation for Science and Technology (FCT) in the field of fluvial dynamics, specifically, the floods of the greatest Portuguese rivers and the results of which are scattered in chapters of books, articles, abstracts, conferences or have never been disclosed as a whole: IDAFRE (An Interdisciplinary Approach to Flood Risk Evaluat...
Influence of processing in food bioactive compounds
Costa, A.; Sousa, A.; Oliveira, B.; Oliveira, C.; Nunes, E.; Ferreira, Isabel; Almeida, I.; Pinho, Olívia; Alves, R.; Casal, S.[abstract]
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisóstomo, J.; Rodrigues, L.; Moedas, A. R.; Monteiro, P.; Cipriano, A.; Seiça, R.Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto–Kakizaki rats were ...
Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, C. M.; Louro, T.; Matafome, P.; Nunes, E.; Monteiro, P.; Seiça, R.Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-...
Sena, C. M.; Nunes, E.; Louro, T.; Proença, T.; Fernandes, R.; Boarder, M. R.; Seiça, R. M.Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA...
Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat
Sena, C. M.; Barosa, C.; Nunes, E.; Seiça, R.; Jones, J. G.Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had higher fasting plasma insulin (219 ± 50 versus 44 ± 14 pmol/l, P < 0.002) and glucose (9.2 ± 2.3 versus 5.5 ± 0.5 mmol/l, P < 0.025). GK rats showed impaired glucose tolerance (IPGTT 2 h p...