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Analysis of shared heritability in common disorders of the brain

Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...


Partitioning the heritability of tourette syndrome and obsessive compulsive dis...

Davis, Lea K.; Yu, Dongmei; Keenan, Clare L.; Gamazon, Eric R.; Konkashbaev, Anuar I.; Derks, Eske M.; Sampaio, Aline S.; Davis, Lea K.; Yu, Dongmei

p. 1-14; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T14:04:29Z No. of bitstreams: 1 10.1371journal.pgen.1003864.pdf: 652592 bytes, checksum: 437d2a27dc80379e2b90d7ee691207ec (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:05:44Z (GMT) No. of bitstreams: 1 10.1371journal.pgen.1003864.pdf: 652592 bytes, checksum: 437d2a27dc80379e2b90d7ee691207ec...

Date: 2014   |   Origin: Oasisbr

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