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Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, Rosa; Moreira, Paula Isabel; Proença, Teresa; Deshpande, Atul; Busciglio, Jorge; Pereira, Cláudia; Oliveira, Catarina Resende

Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence of extracellular senile plaques mainly composed of amyloid-[beta] peptide (A[beta]), intracellular neurofibrillary tangles, and selective synaptic and neuronal loss. AD brains revealed elevated levels of oxidative stress markers which have been implicated in A[beta]-induced toxicity. In the present work we addressed the...

Date: 2008   |   Origin: Estudo Geral - Universidade de Coimbra
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