5 documents found, page 1 of 1
Exploring toxicological interactions in a changing sea: the case of the alkaloi...
Russo, Tania; Coppola, Francesca; Paris, Debora; De Marchi, Lucia; Meucci, Valentina; Motta, Andrea; Carbone, Marianna; Di Cosmo, AnnaThe bisindolic alkaloid caulerpin (CAU) is a bioactive compound isolated from green algae of the genus Caulerpa that are highly invasive in the Mediterranean Sea. On the other side, the purine alkaloid caffeine (CAF) is one of the most globally consumed psychoactive substances and a widespread anthropogenic water pollutant. Both compounds display a large panel of biological properties and are well known to accu...
An alien metabolite vs. a synthetic chemical hazard: an ecotoxicological compar...
Russo, Tania; Coppola, Francesca; Leite, Carla; Carbone, Marianna; Paris, Debora; Motta, Andrea; Di Cosmo, Anna; Soares, Amadeu M. V. M.; Mollo, ErnestoBioactive natural products from marine invasive species may dramatically impact native communities, while many synthetic pharmaceutical drugs are released into the marine environment and have long-lasting harmful effects on aquatic life. Sometimes, metabolites from alien species and synthetic compounds share similar mechanisms of action, suggesting comparable ecotoxicological impacts. This applies to the alkalo...
Oxidative stress, metabolic and histopathological alterations in mussels expose...
Coppola, Francesca; Bessa, Ana; Henriques, Bruno; Russo, Tania; Soares, Amadeu M. V. M.; Figueira, Etelvina; Marques, Paula A. A. P.; Polese, GianlucaThe modern technology brought new engineering materials (e.g. nanostructured materials) with advantageous characteristics such as a high capacity to decontaminate water from pollutants (for example metal(loid)s). Among those innovative materials the synthesis of nanostructured materials (NSMs) based on graphene as graphene oxide (GO) functionalized with polyethyleneimine (GO-PEI) had a great success due to thei...
Effect of the algal alkaloid caulerpin on neuropeptide Y (NPY) expression in th...
Magliozzi, Laura; Maselli, Valeria; Almada, Frederico José Oliveira de; Di Cosmo, Anna; Mollo, Ernesto; Polese, GianlucaRecent studies have suggested that Mediterranean indigenous fish species are affected by bioactive metabolites coming from marine invasive species via food web interactions. In particular, both physiological and behavioural changes in the white sea bream Diplodus sargus were related to caulerpin (CAU), a bisindolic alkaloid particularly abundant in the invasive alga Caulerpa cylindracea, on which the fish activ...
Cephalopods in neuroscience: regulations, research and the 3Rs
Fiorito, Graziano; Affuso, Andrea; Anderson, David B; Basil, Jennifer; Bonnaud, Laure; Botta, Giovanni; Cole, Alison; D'Angelo, LiviaCephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the...