28 documents found, page 1 of 3

Pro-inflammatory polarization and colorectal cancer modulate alternative and in...

Macrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3'UTR (3'UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, in particular in cancer and activated immune cells. Yet, how polarization and colorectal cancer (CRC) cells microenvironment affect 3'UTR-APA and IPA in...

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signal...

Growing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), which can reactivate microglia in a positive feedback mechanism....

The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...

Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and water balance. In this study, skin secretion samples of the fire salamander (Salamandra salamandra) were separated using RP-HPLC and de novo sequenced using MALDI-TOF MS/MS. Next, we used an in silico platform to screen antioxidant molecules in the framework of density functional theory. One of the identified peptides, sal...

Quality of Life and characterization of patients with atopic dermatitis in Port...

OBJECTIVES: To investigate the quality of life (QoL) and to characterize patients with atopic dermatitis (AD) in Portugal. METHODS: This was a cross-sectional study, including patients with AD and other eczemas. Skindex-29, Skindex-teen and Childhood Atopic Dermatitis Impact Scale (CADIS) were the instruments used to assess QoL in adults, teenagers, and children respectively. Complementarily, the SF-12 was used...

Treatment of Pathological Humerus-Shaft Tumoral Fractures with Rigid Static Int...

Objective  This was a retrospective observational study in patients submitted to intramedullary nail fixation after established or impeding pathological humerus-shaft tumoral fracture in the context of disseminated tumoral disease along 22 years of experience at the same institution. Methods  Sample with 82 patients and 86 humeral fixations with unreamed rigid interlocking static intramedullary nail by the ante...

Megapróteses revestidas a prata

As endomegapróteses representam cada vez mais uma solução cirúrgica em situações de perdas ósseas significativas no contexto da cirurgia oncológica, em cirurgia reconstrutiva traumática e em cirurgia de recolocações de próteses articulares. Todavia, estão sujeitas a diferentes tipos de complicações que podem levar, a curto ou a longo prazo, à sua falência mecânica. A principal e mais devastadora é a infeção per...

Genetically engineered-MSC therapies for non-unions, delayed unions and critica...

The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone regenerati...

Limb salvage surgery in extreme situations of prosthetic complications

The treatment of periprosthetic hip and knee infection associated with loss of bone substance, as well as the treatment of the infection of large structural allografts used in tumoral reconstructive surgery, are a major challenge to the orthopaedic surgeon. Indeed, these are chronic conditions which are submitted to multiple surgeries and prolonged antibiotic therapy in socially and professionally vulnerable pa...

Lenalidomide is effective and safe for the treatment of patients with relapsed ...

Patients with multiple myeloma (MM) and severe renal impairment (SRI) have shorter survival than MM patients without renal failure. Although lenalidomide is a highly active drug, this immunomodulatory agent is frequently neglected in this context due to its predominant renal clearance and, consequently, an increased risk of toxicity. This risk might be overcome with the proper lenalidomide dose adjustment to re...

Nocturnal enuresis in children from 5 to 10 years of a personalized health care...