2 documents found, page 1 of 1
Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewirin...
Ferreira, Vitor; Folgueira, Cintia; García-Altares, María; Guillén, Maria; Ruíz-Rosario, Mónica; DiNunzio, Giada; Garcia-Martinez, Irma; Alen, RosaOlanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight gain and metabolic alterations when administered orally to patients. Recently, we demonstrated that, contrarily to the oral treatment which induces weight gain, OLA administered via intraperitoneal (i.p.) in male mice resulted in body weight loss. This protection was due to an increase in energy expenditure (EE) through a mecha...
Determining the contribution of a high-fructose corn syrup formulation to hepat...
DiNunzio, Giada; Belew, Getachew D.; Torres, Alejandra N.; Silva, Joao Gabriel; Silva, Luís P.; Barosa, Cristina; Tavares, Ludgero; Jones, John G.Excessive sugar intake including high-fructose corn syrup (HFCS) is implicated in the rise of obesity, insulin resistance and non-alcoholic fatty liver disease. Liver glycogen synthesis is influenced by both fructose and insulin signaling. Therefore, the effect of HFCS on hepatic glycogenesis was evaluated in mice feeding ad-libitum. Using deuterated water: the fraction of glycogen derived from triose-P sources...