6 documents found, page 1 of 1
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
A unique serum IgG glycosylation signature predicts development of Crohn’s dise...
Gaifem, J; Rodrigues, CS; Petralia, F; Alves, I; Leite-Gomes, E; Cavadas, B; Dias, AM; Moreira-Barbosa, C; Revés, J; Laird, RM; Novokmet, M; Štambuk, JInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 y...
Mannosylated glycans impair normal T-cell development by reprogramming commitme...
Vicente, MM; Alves, I; Fernandes, Â; Dias, AM; Santos-Pereira, B; Pérez-Anton, E; Santos, S; Yang, T; Correia, A; Münster-Kühnel, A; Almeida, ARMT-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic dev...
Promoter methylation of the MGAT3 and BACH2 genes correlates with the compositi...
Klasic, M; Markulin, D; Vojta, A; Samaržija, I; Biruš, I; Dobrinic, P; Ventham, N; Trbojevic-Akmacic, I; Šimurina, M; Štambuk, J; Razdorov, GBackground: Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic changes and IBD. Independent GWA studies have identified genetic variants in the BACH2, IL6ST, LAMB1, IKZF1, and MGAT3 loci to be associated with both IBD and immunoglo...
Glycans as key checkpoints of T cell activity and function
Pereira, MS; Alves, I; Vicente, M; Campar, A; Silva, MC; Padrão, NA; Pinto, V; Fernandes, Â; Dias, AM; Pinho, SSThe immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulatio...
Uma Forma Rara de Gastropatia
Quintela, C; Barbosa, J; Dias, AM; Luz, Z; Bentes, TA doença de Ménétrier é uma gastropatia limitada ao fundo e corpo gástrico associada a hiperplasia foveolar. Os autores descrevem o caso de um homem de 48 anos, seguido na Consulta de Gastrenterologia por dor epigástrica. Laboratorialmente verificou-se hipoalbuminemia e gastrinemia normal. A endoscopia digestiva alta mostrou pregas gástricas gigantes do fundo e corpo. Realizaram-se biópsias que mostraram: hiper...