5 documents found, page 1 of 1
Anti-inflammatory effect of Pterospartum tridentatum leaf extract in acute and ...
Laranjeira, Inês Martins; Gonçalves, João N. D.; Gonçalves, Cátia; Silva, Marlene; Mouta, Nuno; Dias, Alberto C. P.; Pinto-Ribeiro, FilipaPterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 m...
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain b...
Oliveira, Ana; Pinho, Cláudia; Sarmento, Bruno; Dias, Alberto C. P.Search for efficient therapeutic agents for central nervous system (CNS) disorders has been extensive. Nevertheless, blood-brain barrier (BBB) is an obstacle that prevents the majority of compounds to act in these diseases. It is, thus, of extreme relevance the BBB overcome, in order to deliver a drugs therapeutically active concentration to the action site, with the least losses and interaction with other orga...
Neuroprotective Activity of Hypericum perforatum and Its Major Components
Oliveira, Ana Isabel; Pinho, Cláudia; Sarmento, Bruno; Dias, Alberto C. P.Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. John’s wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuro...
Development of polymeric nanoparticles containing neuroprotective compounds of ...
Oliveira, Ana; Pinho, Cláudia; Fonte, Pedro; Sarmento, Bruno; Dias, Alberto C. P.Neurodegenerative process involves several mechanisms. Hypericum perforatum extracts have been used for their antidepressive effects. A selected fraction (HP) of these extracts proved to be neuroprotective.
Phytochemical and antioxidant characterization of Hypericum perforatum alcoholi...
Silva, Bruno A.; Ferreres, Federico; Malva, João O.; Dias, Alberto C. P.The antioxidant potentials of a total ethanolic extract of Hypericum perforatum (TE) and fractions were evaluated and correlated with their phenolic contents. The extracts were fully characterised by HPLC-DAD-MS-MS. Kaempferol 3-rutinoside and rutin-acetyl were identified for the first time in TE extracts. The free radical-scavenging properties of TE (EC50=21 [mu]g dwb/ml) and fractions were studied using DPPH....