2 documents found, page 1 of 1
Genomic-based surveillance reveals high ongoing transmission of multi-drug-resi...
Salvato, Richard Steiner; Reis, Ana Júlia; Schiefelbein, Sun Hee; Gómez, Michael Andrés Abril; Salvato, Stéphanie Steiner; Silva, Larissa Vitória daGenomic-based surveillance on the occurrence of drug resistance and its transmission dynamics has emerged as a powerful tool for the control of tuberculosis (TB). A whole-genome sequencing approach, phenotypic testing and clinical-epidemiological investigation were used to undertake a retrospective population-based study on drug-resistant (DR)-TB in Rio Grande do Sul, the largest state in Southern Brazil. The a...
A influência dos subtipos C, CRF31_BC e B do vírus HIV-1 na progressão da infec...
Nunes, Cynara Carvalho; Matte, Maria Cristina Cotta; Dias, Claudia Fontoura; Araújo, Leonardo Augusto Luvison; Guimarães, Luciano Santos PintoBackground: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. Methods: From July/2004 to December/2005, 135 HIV-infected patients were recruited. The partial pol region was subtyped...