3 documents found, page 1 of 1
iHandU: A Novel Quantitative Wrist Rigidity Evaluation Device for Deep Brain St...
Lopes, EM; Vilas-Boas, MC; Dias, D; Rosas, MJ; Vaz, R; Cunha, JPDeep brain stimulation (DBS) surgery is the gold standard therapeutic intervention in Parkinson's disease (PD) with motor complications, notwithstanding drug therapy. In the intraoperative evaluation of DBS's efficacy, neurologists impose a passive wrist flexion movement and qualitatively describe the perceived decrease in rigidity under different stimulation parameters and electrode positions. To tackle this s...
Therapeutic potential of a-and ß-pinene: A miracle gift of nature
Salehi, B; Upadhyay, S; Orhan, IE; Jugran, AK; Jayaweera, SLD; Dias, D; Sharopov, F; Taheri, Y; Martins, N; Baghalpour, N; Cho, WC; Sharifi-Rad, Ja-and ß-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of ...
Gordon Holmes syndrome due to compound heterozygosity of two new PNPLA6 variant...
Salgado, P; Carvalho, R; Brandão, AF; Jorge, P; Ramos, C; Dias, D; Alonso, I; Magalhães, MBackground: Gordon Holmes syndrome (GHS), characterized by cerebellar ataxia and hypogonadotropic hypogonadism (HH), has been related to recessive mutations in PNPLA6 gene. Aims of the study: Describe one Portuguese family with GHS due to compound heterozygosity of two new PNPLA6 variants. Methods: Report on the clinical presentation, diagnostic and genetic workup to reach GHS diagnosis. Results: The index case...