2 documents found, page 1 of 1
Immunization with the HisAK70 DNA vaccine induces resistance against Leishmania...
Rodrigo, Abel Martínez; Dias, Daniel Silva; Ribeiro, Patrícia Aparecida Fernandes; Roatt, Bruno Mendes; Zubiri, Alicia MasLeishmania amazonensis is the aetiological agent of a broad spectrum of leishmaniosis in South America. It can cause not only numerous cases of cutaneous leishmaniosis but also diffuse cutaneous leishmaniosis. Considering the diversity of parasite species causing different forms of the disease that coexist in the same region, it is desirable to develop a vaccine capable of eliciting cross-protection. We have pr...
In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into...
Mendonça, Débora Vasconcelos Costa; Tavares, Grasiele de Sousa Vieira; Lage, Daniela Pagliara; Soyer, Tauane Gonçalves; Carvalho, Lívia MendesNew therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishmania parasites, but low toxicity in mammalian hosts. Flau-A is a naphthoquinone derivative recently showed to prese...