2 documents found, page 1 of 1
Design and synthesis of new Benzophenone derivatives with in vivo anti-inflamma...
Santos, Marcelo H. dos; Januario, Jaqueline P.; Souza, Thiago B. de; Lavorato, Stefânia N.; Maiolini, Tatiane C. S.; Domingos, Olívia S.A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...
Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities...
Moreira, Maria Eliza C.; Sousa, Grasiely F. de; Aguilar, Mariana G. de; Dias, Danielle F.; Takahashi, Jacqueline A.; Vieira Filho, Sidney A.The new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-one (4). The structures and stereochemistry of the novel triterpenoids were established by IR, 1D/2D NMR and HR-APCIMS spectral data. ...