4 documents found, page 1 of 1
Synthesis, characterization, and structural determination of copper(II) complex...
Santos, Marcelo Henrique Dos; Gonçalves, Cristiane Batista; Marinho, Maria Vanda; Dias, Danielle Ferreira; Martins, Felipe TerraFour mononuclear copper(II) complexes, [Cu(LFQM-115)2] (1), [Cu(LFQM-116)2] (2), [Cu(LFQM-117)2] (3) and [Cu(octyloxy)2] (4) [LFQM-115 = 2-hydroxy-4-O-methylbenzophenone (C14H11O3), LFQM-116 = 2-hydroxy-4-O-butylbenzophenone (C17H18O3), LFQM-117 = 2-hydroxy-4-O-(33-dimethylallyl)benzophenone (C18H18O3) and octyloxy = 2-hydroxy-4-O-octylbenzophenone (C21H25O3)], have been prepared and investigated by infrared sp...
Design and synthesis of new benzophenone derivatives with in vivo anti-inflamma...
Januário, Jaqueline Pereira; Souza, Thiago Belarmino de; Lavorato, Stefânia Neiva; Maiolini, Tatiane Cristina Silva; Domingos, Olívia da SilvaA series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...
Synthesis, activity and docking studies of eugenol-based glucosides as new agen...
Santos, Marcelo Henrique dos; Hipólito, Taciane Maíra Magalhães; Bastos, Guilherme Tadeu Lemos; Barbosa, Thúlio Wliandon LemosSeventeen new synthetic derivatives of eugenol (6, 8–15 and 8′‐15′) were planned following literature reports on antifungal activities of nitroeugenol and eugenol glucoside. The anti‐Candida activity of these compounds was investigated by in vitro assay and the cytotoxicity evaluation was performed with the most active compounds. The peracetylated glucosides presented better biological results than their hydrox...
Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities...
Sousa, Grasiely Faria de; Aguilar, Mariana Guerra de; Dias, Danielle Ferreira; Takahashi, Jacqueline Aparecida; Moreira, Maria Eliza de CastroThe new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-one (4). The structures and stereochemistry of the novel triterpenoids were established by IR, 1D/2D NMR and HR-APCIMS spectral data. ...