6 documents found, page 1 of 1
Characterization of Genetic Polymorphisms CYP2R1 rs2060793 and CYP2R1 rs1279471...
Varandas, Tatiana; Dias, Francisca; Sousa, Ana; Sousa, Maria; Medeiros, RuiBackground: Endometriosis is an estrogen-dependent gynecologic disorder defined by the presence of endometrium outside the uterine cavity [1, 2]. Vitamin D is a steroid hormone known for its importance in various biological processes [3]. Vitamin D may play a direct role in the changes that the endometrium undergoes during the menstrual cycle, as endometrial tissue also expresses enzymes involved in metabolism ...
Antitumor effect of chalcone derivatives against human prostate (LNCaP and PC-3...
Horta, Bruno; Freitas-Silva, Joana; Silva, Jani; Dias, Francisca; Teixeira, Ana Luísa; Medeiros, Rui; Cidade, Honorina; Pinto, MadalenaChalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer agents. In this work, the effect of chalcones 1–18 against the metabolic viability of cervical (HeLa) and prostate (PC-3 and LNCaP) tumor cell lines was tested, to compare the activity against solid and liquid tumor cells. Their effect was also evaluated on the Jurkat cell line. Chalcone 16 showed the high...
Characterization of genetic polymorphisms CYP2R1 rs2060793 and CYP2R1 rs1279471...
Varandas, Tatiana; Dias, Francisca; Sousa, Ana; Amorim, Manuela; Medeiros, RuiEndometriosis is an estrogen-dependent gynecologic disorder defined by the presence of endometrium outside the uterine cavity. Vitamin D is a steroid hormone known for its importance in various biological processes. Vitamin D may play a direct role in the changes that the endometrium undergoes during the menstrual cycle, as endometrial tissue also expresses enzymes involved in metabolism. The study of genetic p...
Effect of 1-carbaldehyde-3,4-dimethoxyxanthone on prostate and HPV-18 positive ...
Medeiros, R.; Horta, Bruno; Freitas-Silva, Joana; Silva, Jani; Dias, Francisca; Sousa, Emília; Pinto, Madalena; Cerqueira, FátimaXanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4- dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new panel of cancer cells, namely cervical cancer (HeLa), androgen-sensitive (LNCaP) and androgen-independent (PC-3) prostate cancer, and nonsolid tumor derived cancer (J...
Effect of 1-carbaldehyde-3,4-dimethoxyxanthone on prostate and HPV-18 positive ...
Medeiros, Rui; Horta, Bruno; Freitas-Silva, Joana; Silva, Jani; Dias, Francisca; Sousa, Emília; Pinto, Madalena; Cerqueira, FátimaXanthone derivatives have shown promising antitumor properties, and 1-carbaldehyde-3,4-dimethoxyxanthone (1) has recently emerged as a potent tumor cell growth inhibitor. In this study, its effect was evaluated (MTT viability assay) against a new panel of cancer cells, namely cervical cancer (HeLa), androgen-sensitive (LNCaP) and androgen-independent (PC-3) prostate cancer, and nonsolid tumor derived cancer (Ju...
Cancer cells’ metabolism dynamics in renal cell carcinoma patients’ outcome: in...
Morais, Mariana; Dias, Francisca; Nogueira, Inês; Leão, Anabela; Gonçalves, Nuno; Araújo, Luís; Granja, Sara Costa; Baltazar, Fátima; Teixeira, Ana L.The cancer cells’ metabolism is altered due to deregulation of key proteins, including glucose transporter 1 (GLUT-1), whose mRNA levels are influenced by microRNAs (miRNAs). Renal cell carcinoma (RCC) is the most common and lethal neoplasia in the adult kidney, mostly due to the lack of accurate diagnosis and follow-up biomarkers. Being a metabolic associated cancer, this study aimed to understand the hsa-miR-...