28 documents found, page 1 of 3
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Black-and-White Ruffed Lemur (Varecia variegata) in captivity : analysis of the...
Silva, Carolina; Requicha, João F.; Martins, José J.; Duarte, Aida; Dias, Isabel R.; Viegas, Carlos A.; Saavedra, Maria J.This study aimed to characterize the susceptibility profile to antibiotics and biofilm formation of Gram-negative bacterial isolates obtained from the oral cavity of the black-and-white ruffed lemur (Varecia variegata). From eight individuals from a zoo located in Portugal, samples of the oral microbiota were collected with sterile swabs and then placed in closed tubes with a transport medium. Culture was carri...
Toward spinning greener advanced silk fibers by feeding silkworms with nanomate...
Ramos, Nuno; Miranda, Margarida S.; Franco, Albina Ribeiro; Silva, Simone S.; Azevedo, Jorge; Dias, Isabel R.; Reis, R. L.; Viegas, CarlosSilk has been used in several biomedical applications, including tissue engineering, drug delivery systems, biomedical implants, and diagnostic medical devices, due to its attractive intrinsic properties such as biocompatibility, controllable biodegradability, and excellent mechanical properties. In recent years, several attempts have been made to produce silk fibers with improved properties and new functionali...
Bioengineered surgical repair of a chronic oronasal fistula in a cat using auto...
Soares, Carla S.; Barros, Luís C.; Saraiva, Virgínia; Gomez-Florit, Manuel; Babo, Pedro Miguel Sousa; Dias, Isabel R.; Reis, R. L.; Carvalho, Pedro P.Clinical summary: A tissue engineering approach was used to aid the surgical repair of a chronic oronasal fistula (ONF) in a 13-year-old cat. A three-dimensional (3D) printed mesh, tailored to the size and shape of the ONF, was created to support a soft tissue flap used to close the defect; and also to provide a matrix for mesenchymal stromal cells present in bone marrow aspirate and bioactive cytokines and gro...
Preclinical and translational studies in small ruminants (sheep and goat) as mo...
Dias, Isabel R.; Camassa, José A.; Bordelo, João A.; Babo, Pedro Miguel Sousa; Viegas, Carlos A.; Dourado, N.; Reis, R. L.; Gomes, Manuela E.Purpose of the Review: This review summarizes research on the use of sheep and goats as large animal models of human osteoporosis for preclinical and translational studies. Recent Findings: The most frequent osteoporotic sheep model used is the ovariectomized sheep with 12 months post-operatively or more and the combined treatment of ovariectomized sheep associated to calcium/vitamin D-deficient diet and glucoc...
Bone turnover markers in sheep and goat: a review of the scientific literature
Camassa, José A.; Diogo, Camila C.; Sousa, Cristina P.; Azevedo, Jorge T.; Viegas, Carlos A.; Reis, R. L.; Dourado, N.; Dias, Isabel R.Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also dur...
Evaluation of bone turnover markers and serum minerals variations for predictin...
Sousa, Cristina P.; Lopez-Peña, Mónica; Guzon, Fernando M.; Abreu, Humberto V. de; Luís, Maurino R.; Viegas, Carlos A.; Camassa, José A.Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers ...
Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifesp...
Camassa, José A.; Diogo, Camila C.; Bordelo, João P. A.; Bonelli, Marília de A.; Viegas, Carlos A.; Azevedo, Jorge T.; Dourado, Nuno; Dias, Isabel R.Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much ...
Bone turnover markers for early detection of fracture healing disturbances: A r...
Sousa, Cristina P.; Dias, Isabel R.; Lopez-Peña, Mónica; Camassa, José A.; Lourenço, Paulo J.; Judas, Fernando M.; Gomes, Manuela E.; Reis, Rui L.Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for...
Biological evaluation of intervertebral disc cells in different formulations of...
Khang, G.; Lee, S. K.; Kim, H. N.; Silva-Correia, Joana; Gomes, Manuela E.; Viegas, C. A. A.; Dias, Isabel R.; Oliveira, Joaquim M.; Reis, R. L.Gellan gum (GG)-based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine-tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formula...