The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome ...
Calcium plays an important role in barrier function repair and skin homeostasis. In particular, calcium phosphates (CaPs) are well established materials for biomedical engineering due to their biocompatibility. To generate biomaterials with a more complete set of biological properties, previously discarded silk sericin (SS) has been recovered and used as a template to grow CaPs. Crucial characteristics for skin...
This work is supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following Projects: UIDB/04044/2020, UIDP/04044/2020. This study was also supported by PAMI-OTEIRO/0328/2013 (N 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362) and SpinningTNT (POCI-01-02B7-FEDER-069285). This work is also supported by the research grants 2021.04541.BD awarded to Carolina A. M. Ferreira and 2021.05893.BD aw...
Tecnologia FCT/MCTES (PIDDAC) and Centro2020, Grant/Award Number: UIDB/04044/2020 and UIDP/04044/2020; Associate Laboratory ARISEand PAMI, Grant/Award Number: LA/P/0112/2020 and ROTEIRO/0328/2013; Research Unit INESC MN and FCT, Grant/Award Number: UID/05367/2020 and UIDB/50022/2020.; Aim: This study aimed to experimentally validate a computational fluid dynamics (CFD) model, using micro-particle image velocime...
This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following projects: CDRSP: UIDB/04044/2020, UIDP/04044/2020 and MARE: UIDB/04292/2020 and UIDP/04292/2020. This study was also supported by PAMI-ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362), SpinningTNT (POCI-01-02B7-FEDER-069285), and the project LA/P/0069/2020 granted to the Associate Laboratory...
Calcium plays an important role in barrier function repair and skin homeostasis. In particular, calcium phosphates (CaPs) are well established materials for biomedical engineering due to their biocompatibility. To generate biomaterials with a more complete set of biological properties, previously discarded silk sericin (SS) has been recovered and used as a template to grow CaPs. Crucial characteristics for skin...
In situ cross-linked hydrogels have the advantage of effectively fulfilling the wound in its shape and depth. Amongst the new generation of natural-based biopolymers being proposed for wound care and skin regeneration, silk sericin is particularly interesting due to its exceptional properties such as biocompatibility, biodegradability, and antioxidant behavior, among others. In this study, a new enzyme-mediated...
Brown seaweeds are recognized sources of compounds with a wide range of properties and applications. Within these compounds, phlorotannins are known to possess several bioactivities (e.g., antioxidant, anti-inflammatory, and antimicrobial) with potential to improve wound healing. To obtain phlorotannins enriched extracts from Undaria pinnatifida, a biorefinery was set using low cost industry-friendly methodolog...
Decellularization is a process that consists on the removal of immunogenic cellular material from a tissue, so that it can be safely implanted as a functional and bioactive scaffold. Most decellularization protocols rely on the use of harsh chemicals and very long washing processes, leading to severe changes in the ultrastructure and loss of mechanical integrity. To tackle these challenges, supercritical carbon...