5 documents found, page 1 of 1
Efeito antinociceptivo da riparina IV em modelos animais: mecanismos de ação en...
Dias, Marília LeiteFrom the green fruit of Aniba riparia (Nees) Mez, some alcamides with interesting therapeutic potential, named Riparinas, are found. Through a process of chemical modification, a structural analogue of these substances, Riparina IV, was synthesized. Previous studies have shown that it has anxiolytic and antidepressant effects, as well as antinociceptive effect. The present work was developed with the approval o...
Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or para...
Rocha, Nayrton Flávio Moura; Rios, Emiliano Ricardo Vasconcelos; Carvalho, Alyne Mara Rodrigues; Freire, Leonardo Vasconcelos; Dias, Marília LeitePurpose: Our great interest in this work was study the synergism between L-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (L-tryptophan metabolite) and these analgesics agents utilizing a robust methodology. Methods: We performed the writhing test induced by acetic acid in mice to evaluate the antinociceptive effect of the treatments isolated and combined (p.o. and i.p.). Do...
Evaluation of the anti-inflammatory activity of riparin II (O-methil- N-2-hidro...
Carvalho, Alyne Mara Rodrigues de; Rocha, Nayrton Flávio Moura; Vasconcelos, Leonardo Freire; Rios, Emiliano Ricardo Vasconcelos; Dias, Marília LeiteRiparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritoniti...
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate
Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Carvalho, Alyne Mara Rodrigues; Vasconcelos, Leonardo Freire; Dias, Marília LeiteBackground: Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to describe the antinociceptive action of CAT. Methods: The acetic acid-induced writhing test and the paw-licking test, in whic...
Atividade antinociceptiva da riparina IV : participação dos receptores TRPV1, T...
Dias, Marília LeiteRiparin IV, an alkamide synthesized from Aniba riparia, was tested in standard animal models of pain, as well as the possible mechanisms of action involved. It was used Swiss mice (20-30g), and Riparin IV was administred acutely in all tests, at the doses of 25 and 50 mg/kg, by gavage. It was used the tests of abdominal writhing induced by acetic acid, hot plate test, formalin test, mechanical hypernociception ...