Encontrados 19 documentos, a visualizar página 1 de 2
A satisfação e qualidade do evento Triatlo de São Martinho do Porto 2023
Jacinto, Miguel; Sousa, Marlene; Margarido, Cristóvão; Varela, Jorge Alexandre Barroca de Sousa; Dias, Sérgio; Santos, Ricardo; Monteiro, DiogoO objetivo deste estudo foi analisar a satisfação e qualidade do evento Triatlo de São Martinho do Porto 2023, considerando as perceções dos participantes. Responderam a um questionário online 208 participantes, com idades compreendidas entre os 14 e os 65 (média, M = 41.29; desvio padrão, DP = 11.28), dos quais 71% eram do sexo masculino. Na dimensão Qualidade Percebida, a pontuação atribuída pelos participant...
Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer c...
Nobrega-Pereira, Sandrina; Santos, Francisco; Oliveira Santos, Miguel; Serafim, Teresa; Lopes, Ana Patrícia; Coutinho, Diogo; Carvalho, FilipaMost cancer-related deaths are due to metastases. Systemic factors, such as lipid-enriched environments [as low-density lipoprotein (LDL)-cholesterol], favor breast cancer, including triple-negative breast cancer (TNBC) metastasis formation. Mitochondria metabolism impacts TNBC invasive behavior but its involvement in a lipid-enriched setting is undisclosed. Here we show that LDL increases lipid droplets, induc...
The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Res...
Abdulghani, Saba; Afonso, Ângela; Castillo, Mireia; Martín-Fernández, Javier; Franco, Inês; Parreira, Bruna; Couto, Ana; Bruges-Armas, JácomeN/a.; N/a.
On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping
Esperança-Martins, Miguel; F. Duarte, Iola; Rodrigues, Mara; Soares do Brito, Joaquim; López-Presa, Dolores; Costa, Luís; Fernandes, IsabelSoft tissue sarcomas (STS) prognosis is disappointing, with current treatment strategies being based on a "fit for all" principle and not taking distinct sarcoma subtypes specificities and genetic/metabolic differences into consideration. The paucity of precision therapies in STS reflects the shortage of studies that seek to decipher the sarcomagenesis mechanisms. There is an urge to improve STS diagnosis preci...
CavBench: a benchmark for protein cavity detection methods
Dias, Sérgio; Simões, Tiago M. C.; Fernandes, Francisco; Martins, Ana Mafalda; Ferreira, Alfredo; Jorge, Joaquim A; Gomes, AbelExtensive research has been applied to discover new techniques and methods to model protein-ligand interactions. In particular, considerable efforts focused on identifying candidate binding sites, which quite often are active sites that correspond to protein pockets or cavities. Thus, these cavities play an important role in molecular docking. However, there is no established benchmark to assess the accuracy of...
An antisense transcript mediates MALAT1 response in human breast cancer
Gomes, Carla Pereira; Nobrega-Pereira, Sandrina; Domingues Silva, Ana Beatriz; Rebelo, Kenny; Alves-Vale, Catarina; Marinho, Sérgio; Carvalho, TâniaBackground: Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical applications during aging and disease. As example, targeting of MALAT1, a highly conserved lncRNA originally identified in metastatic non-small cell lung cancer, has shown promising results in cancer regr...
Meeting the needs of breast cancer: a nucleolin’s perspective
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João NunoA major challenge in the management of breast cancer disease has been the development of metastases. Finding new molecular targets and the design of targeted therapeutic approaches to improve the overall survival and quality of life of these patients is, therefore, of great importance. Nucleolin, which is overexpressed in cancer cells and tumor-associated blood vessels, have been implicated in various processes...
Therapeutic implications of the molecular and immune landscape of triple-negati...
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João NunoTreatment and management of breast cancer imposes a heavy burden on public health care, and incidence rates continue to increase. Breast cancer is the most common female neoplasia and primary cause of death among women worldwide. The recognition of breast cancer as a complex and heterogeneous disease, comprising different molecular entities, was a landmark in our understanding of this malignancy. Valuing the im...
Republicans and Democrats: Who has a voice on Twitter? The case of the 2016 US ...
Rodrigues, Judite; Dias, SérgioTwitter has become a space for political deliberation and confrontational positions, during election time. Therefore, the prime objective of this research focused on understanding which U.S. political force – republicans or democrats – had a more substantial presence on Twitter, during the presidential election of 2016. As we were trying to decipher this issue, we were also trying to understand the power of the...
Multi-GPU-Based Detection of Protein Cavities using Critical Points
Dias, Sérgio; Nguyen, Quoc; Jorge, Joaquim A; Gomes, AbelProtein cavities are specific regions on the protein surface where ligands (small molecules) may bind. Such cavities are putative binding sites of proteins for ligands. Usually, cavities correspond to voids, pockets, and depressions of molecular surfaces. The location of such cavities is important to better understand protein functions, as needed in, for example, structure-based drug design. This article introd...