2 documents found, page 1 of 1
In vitro and in silico evaluation of the schistosomicidal activity of eugenol d...
Souza,Isabella Maria Monteiro de; Novaes,Romulo Dias; Gonçalves,Reggiani Vilela; Fialho,Felipe Leonardo Bley; Carvalho,Diogo TeixeiraAbstract Background Eugenol shows both antibacterial and antiparasitic activities, suggesting that it might be evaluated as an option for the treatment of praziquantel-resistant schistosome. Methods The in vitro activities of three eugenol derivatives (FB1, FB4 and FB9) on adult worms from Schistosoma mansoni were examined by fluorescence and scanning electron microscopy to analyze effects on the excretory syst...
Reações de carbociclização radicalar de orto-iodoaliloxibenzoatos derivados de ...
Binatti,Ildefonso; Alves,Rosemeire Brondi; Souza Filho,José Dias de; Dias,Danielle Ferreira; Prado,Maria Auxiliadôra Fontes; Alves,Ricardo JoséTwo ortho-iodoallyloxybenzoates, methyl 4-O-allyl-2,3-di-O-benzyl-6-O-(2-iodobenzoyl)- alpha-D-glucopyranoside (3) and methyl 4-O-allyl-2,3-di-O-benzyl-6-O-(2-iodobenzoyl)- alpha-D-galactopyranoside (4) were synthesized in seven conventional steps from methyl alpha-D-glucopyranoside and methyl alpha-D-galactopyranoside, respectively. Bu3SnH-mediated aryl radical cyclization of 3 provided exclusively the hydroge...